甜菜碱神经保护作用的研究进展

doi:10.19586/j.2095-2341.2024.0163

生物技术进展 ›› 2025, Vol. 15 ›› Issue (2): 220-225.DOI: 10.19586/j.2095-2341.2024.0163

• 进展评述 • 上一篇

甜菜碱神经保护作用的研究进展

赵天源(), 王菁, 王雨露, 袁春森, 陈薛钗()

北京工业大学化学与生命科学学院，北京 100124

收稿日期:2024-10-23 接受日期:2025-02-12 出版日期:2025-03-25 发布日期:2025-04-29
通讯作者: 陈薛钗
作者简介:赵天源 E-mail: zhaoty719@emails.bjut.edu.cn；
基金资助:
国家自然科学基金项目-面上项目(82271283)

Research Progress on Neuroprotective Effects of Betaine

Tianyuan ZHAO(), Jing WANG, Yulu WANG, Chunsen YUAN, Xuechai CHEN()

College of Chemistry and Life Science，Beijing University of Technology，Beijing 100124，China

Received:2024-10-23 Accepted:2025-02-12 Online:2025-03-25 Published:2025-04-29
Contact: Xuechai CHEN

摘要/Abstract

摘要：

甜菜碱作为一种天然存在的化合物，其独特的生物化学特性和多种功能使其在神经退行性疾病、神经炎症以及神经损伤的治疗中具有潜在的应用价值。甜菜碱具有促进同型半胱氨酸代谢，降低氧化应激水平，调节γ-氨基丁酸表达等作用，对包括阿尔茨海默病、抑郁症、帕金森综合征等多种神经系统疾病均起到一定的治疗作用，且不良反应较小。然而，目前关于甜菜碱在神经保护方面的研究尚处于初级阶段，还需要进一步探索其作用机制和最佳应用方案。综述了甜菜碱在神经保护领域的研究进展，以期为神经系统疾病的治疗提供新的思路和方法。

关键词: 甜菜碱, 神经保护, 同型半胱氨酸, 氧化应激, 神经递质

Abstract:

As a naturally occurring compound， betaine has attracted widespread attention in the field of neuroprotection in recent years. The unique biochemical properties and multiple functions of betaine make it has potential application value in the treatment of neurodegenerative diseases， neuroinflammation and nerve injury. Betaine has the functions of promoting the metabolism of homocysteine， reducing the level of oxidative stress， regulating the expression of γ-aminobutyric acid， etc. It has a therapeutic role in various neurological diseases such as Alzheimer's disease， depression， and Parkinson's disease， with relatively minor side effects. However， current research on the neuroprotective effects of betaine is still in its infancy， and further exploration is needed to understand its mechanism of action and optimal application scenarios. The article reviewed the research progress on the neuro protective effects of betaine， aiming to provide new ideas and methods for the treatment of neurological diseases.

Key words: betaine, neuroprotection, homocysteine, oxidative stress, neurotransmitter

中图分类号:

Q189

赵天源, 王菁, 王雨露, 袁春森, 陈薛钗. 甜菜碱神经保护作用的研究进展[J]. 生物技术进展, 2025, 15(2): 220-225.

Tianyuan ZHAO, Jing WANG, Yulu WANG, Chunsen YUAN, Xuechai CHEN. Research Progress on Neuroprotective Effects of Betaine[J]. Current Biotechnology, 2025, 15(2): 220-225.

图/表 2

参考文献 33

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甜菜碱神经保护作用的研究进展

Research Progress on Neuroprotective Effects of Betaine

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