关键词: 糖尿病肾病, 雷帕霉素靶蛋白, 自噬, 炎症反应, 氧化应激

Abstract: Diabetic nephropathy (DN) is one of the most common complications of diabetes. Because of its high incidence and related to the risks of advanced kidney disease, cardiovascular disease and premature death, DN has become a global public health problem, but its pathogenesis is still unclear. Mammalian target of rapamycin (mTOR) is a serine/threonine protease, which plays an important role in delaying apoptosis and promoting cell division, cell survival and angiogenesis. Recent studies have shown that mTOR exists in the key steps of DN progression, including autophagy, inflammation and oxidative stress. Therefore, the research progress of mTOR-mediated autophagy, inflammation and oxidative stress signaling pathways in the pathogenesis of DN was reviewed, in order to provide theoretical reference for the treatment and prevention of DN.

Key words: diabetic nephropathy, mTOR, autophagy, inflammatory reaction, oxidative stress