关键词: 阿尔茨海默病, 2型糖尿病, 淀粉样蛋白, Tau蛋白

Abstract: Alzheimers disease (AD) is a chronic disease characterized by cognitive deficiency. Currently, there is no effective cure drug for AD. Due to the significant increase in the number of patients, the exploration of drugs for the treatment of AD has become a research hotspot at home and abroad. In recent years, epidemiological studies have shown that type 2 diabetes mellitus is a risk factor for AD, and both of them share common pathophysiological mechanisms, such as insulin resistance, amyloid-β protein deposition, Tau hyperphosphorylation, inflammatory response and oxidative stress. Therefore, screening drugs for AD from existing anti-diabetic drugs is a trend of current research. More and more studies have confirmed that hypoglycemic drugs (such as insulin, metformin, etc.) have a beneficial effect on improving AD lesions. In this paper,  we summerized the progress of treatment of AD with antidiabetes drugs. The correlation between AD and type 2 diabetes mellitus and the treatment of AD with anti-diabetic drugs was also reviewed, in order to broaden the ideas for the treatment of AD.

Key words: Alzheimers disease, type 2 diabetes mellitus, amyloid-&beta, protein, Tau protein