关键词: 内质网应激, 糖尿病肾病, 未折叠蛋白反应

Abstract: Diabetic nephropathy (DN) is the most common microvascular complication of diabetes and one of the main causes of secondary renal disease leading to end-stage renal disease (ESRD). A variety of factors such as lack of oxygen, oxidative stress, virus infection, genetic mutations can lead to an imbalance in the homeostasis of the endoplasmic reticulum, and the accumulation of a large number of unfolded and misfolded proteins, namely the formation of endoplasmic reticulum stress (ERS), thereby activating the unfolded protein response (UPR) mediated three classic adaptive response pathways to restore endoplasmic reticulum homeostasis and cell viability. However, if the stimulation is too strong or persistent, the apoptotic signaling pathway will be activated. A large number of studies have shown that ERS is related to the occurrence and development of DN and is involved in the process of different types of renal cell injury. Therefore, ERS as an effective target for the treatment of DN has a very important research prospect. Therefore, the regulation of  ERS may provide a new theoretical support for the treatment of DN. In this paper, ERS associated signaling pathways and their roles in DN were reviewed, which was expected to provide reference for DN treatment research.

Key words: endoplasmic reticulum stress, diabetic nephropathy, unfolded protein response