自噬与细胞凋亡：相互作用及其在疾病中的作用

doi:10.19586/j.2095-2341.2025.0028

生物技术进展 ›› 2025, Vol. 15 ›› Issue (4): 622-626.DOI: 10.19586/j.2095-2341.2025.0028

• 进展评述 • 上一篇

自噬与细胞凋亡：相互作用及其在疾病中的作用

朱丽娜(), 宋志灵()

青岛科技大学化学与分子工程学院，山东青岛 266045

收稿日期:2025-03-03 接受日期:2025-04-01 出版日期:2025-07-25 发布日期:2025-09-08
通讯作者: 宋志灵
作者简介:朱丽娜 E-mail: 1608641716@qq.com；
基金资助:
山东省自然科学基金项目(322024054)

Autophagy and Apoptosis: Interactions and Their Role in Disease

Lina ZHU(), Zhiling SONG()

College of Chemistry and Molecular Engineering，Qingdao University of Science and Technology，Shandong Qingdao 266045，China

Received:2025-03-03 Accepted:2025-04-01 Online:2025-07-25 Published:2025-09-08
Contact: Zhiling SONG

摘要/Abstract

摘要：

自噬与细胞凋亡是维持细胞稳态的关键生理过程，其相互作用在肿瘤、神经退行性疾病及心血管疾病中具有重要的病理意义。现有研究对二者动态调控网络的分子机制解析尚不完善，且在疾病治疗中靶向调控自噬-凋亡平衡的策略缺乏精准性。研究表明，通过双向调控机制和靶向关键枢纽蛋白可以协同抑制凋亡并激活自噬。综述总结了自噬与凋亡相互作用的机制及其在肿瘤、神经退行性疾病、心脏病中的研究进展，以期为解析细胞死亡调控网络提供理论框架，为开发基于自噬-凋亡平衡调控的精准治疗策略奠定重要基础。

关键词: 自噬, 细胞凋亡, 肿瘤, 神经退行性疾病

Abstract:

Autophagy and apoptosis are the key physiological processes to maintain cell homeostasis， and their interaction has important pathological significance in tumors， neurodegenerative diseases and cardiovascular diseases. The molecular mechanism of the two dynamic regulatory networks has not been fully analyzed in the existing studies， and the strategies targeting the regulation of autophagy and apoptosis balance in disease treatment are still lacking in accuracy. Studies have shown that through a bidirectional regulatory mechanism and targeting key hub proteins can synergically inhibit apoptosis and activate autophagy. The review summarized the interaction mechanism between artophagy and apoptosis， as well as the research progress in tumors， neurodegenerative diseases， and heart disease， in order to provide a theoretical framework for analyzing cell death regulatory networks and lay an important foundation for developing precise therapeutic strategies based on the balance regulation of autophagy and apoptosis.

Key words: autophagy, cell apoptosis, tumor, neurodegenerative disease

中图分类号:

Q291

朱丽娜, 宋志灵. 自噬与细胞凋亡：相互作用及其在疾病中的作用[J]. 生物技术进展, 2025, 15(4): 622-626.

Lina ZHU, Zhiling SONG. Autophagy and Apoptosis: Interactions and Their Role in Disease[J]. Current Biotechnology, 2025, 15(4): 622-626.

图/表 3

图1 自噬形成过程示意图[3]

Fig. 1 Schematic diagram of autophagy formation process[3]

图2 自噬与凋亡之间的关系示意图[10]

Fig. 2 Schematic diagram of the relationship between autophagy and apoptosis[10]

图3 小分子筛选技术路线示意图[17]

Fig. 3 Schematic diagram of small molecule screening technology[17]

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自噬与细胞凋亡：相互作用及其在疾病中的作用

Autophagy and Apoptosis: Interactions and Their Role in Disease

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