亚精胺缓解细胞衰老及衰老相关疾病的研究进展

doi:10.19586/j.2095-2341.2024.0034

生物技术进展 ›› 2024, Vol. 14 ›› Issue (3): 388-398.DOI: 10.19586/j.2095-2341.2024.0034

• 进展评述 • 上一篇

亚精胺缓解细胞衰老及衰老相关疾病的研究进展

李鸿博(), 陈朱玥, 吕新星()

山东第一医科大学临床与基础医学院，济南 250000

收稿日期:2024-02-29 接受日期:2024-03-25 出版日期:2024-05-25 发布日期:2024-06-18
通讯作者: 吕新星
作者简介:李鸿博 E-mail: li463195983@qq.com；
基金资助:
2023年山东第一医科大学省级大学生创新训练计划项目(S202310439009);山东省自然科学基金青年项目(ZR2021QC030)

Recent Progress on Spermidine Alleviating Cell Senescence and Aging-related Diseases

Hongbo LI(), Zhuyue CHEN, Xinxing LYU()

Institute of Clinical and Basic Medicine，Shandong First Medical University，Jinan 250000，China

Received:2024-02-29 Accepted:2024-03-25 Online:2024-05-25 Published:2024-06-18
Contact: Xinxing LYU

摘要/Abstract

摘要：

衰老是机体随着时间推移而发生的不可抗拒的自然变化，表现为生物体形态结构的改变和生理功能的衰退，同时伴随着多种老年性疾病的发生。亚精胺作为天然的多胺类物质，在抑制机体衰老进程中发挥着重要作用。最近的研究表明，亚精胺通过激活细胞自噬，清除受损的线粒体，干预脂肪代谢和调节细胞周期等方式，清除衰老细胞，维持组织微环境稳定，抑制衰老相关疾病的发生和进展。系统地阐述了亚精胺的体内和体外的合成过程，缓解细胞衰老的分子机制，以及在减缓机体衰老生理过程和多种衰老相关疾病中的治疗作用，以期为衰老相关疾病的转归与临床治疗提供参考。

关键词: 亚精胺, 自噬, 衰老, 老年病

Abstract:

Aging is an irresistible natural change in the organisms over time， manifested by changes of the morphological structures， decline of physiological functions， and occurrence of many geriatric diseases. Spermidine， a natural polyamine， shows great potential in alleviating the aging process. Recent studies showed that spermidine could clean senescent cells， repair damaged tissues， reduce the occurrence of aging-related diseases by activating autophagy， clean damaged mitochondria， interfere the lipid metabolism and regulate cell cycles. The major synthesis processes in vivo and in vitro， molecular mechanisms to alleviate aging， and therapeutic roles in aging-related diseases of spermidine were systematically described in this review， in order to provide reference for the prognosis and clinical treatment of age-related diseases.

Key words: spermidine, autophagy, senescence, geriatric diseases

中图分类号:

Q291

李鸿博, 陈朱玥, 吕新星. 亚精胺缓解细胞衰老及衰老相关疾病的研究进展[J]. 生物技术进展, 2024, 14(3): 388-398.

Hongbo LI, Zhuyue CHEN, Xinxing LYU. Recent Progress on Spermidine Alleviating Cell Senescence and Aging-related Diseases[J]. Current Biotechnology, 2024, 14(3): 388-398.

图/表 4

图1 亚精胺结构式

Fig. 1 The structure of spermidine

图2 哺乳动物体内的亚精胺合成图A：S-腺苷甲硫氨酸合成途径（Sam合成途径）；B：以鸟氨酸为原料生成腐胺的过程；C：天冬氨酸半醛合成途径（Asa合成途径）；D：亚精胺与精胺的转化关系

Fig. 2 The process of spermidine synthesis in mammalian cells

图3 以谷氨酸和1,3-丙二胺为底物生物合成亚精胺的途径

Fig. 3 The biosynthesis of spermidine with glutamic acid and 1,3-propanediamine as substrates

表1 不同种类的亚精胺微生物发酵法

Table 1 List of different types of microbial fermentation methods for spermidine

时间	菌株/平台	方法	底物	产量	参考文献
2017年	Saccharomyces cerevisiae	代谢工程	葡萄糖/木糖	224.0 mg·L^-1	[17]
2020年	Bacillus amyloliquefaciens	代谢工程	果糖/木糖	227.4 mg·L^-1	[19]
2021年	Saccharomyces cerevisiae	代谢工程	葡萄糖	2.3 g·L^-1	[21]
2021年	酶（MAT+SAMDC）	酶催化	Sam和腐胺	3.7 g·L^-1	[18]

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亚精胺缓解细胞衰老及衰老相关疾病的研究进展

Recent Progress on Spermidine Alleviating Cell Senescence and Aging-related Diseases

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