生物技术进展 ›› 2011, Vol. 1 ›› Issue (2): 122-129.DOI: 10.3969/j.issn.2095-2341.2011.02.08

• 进展评述 • 上一篇    下一篇

人表皮细胞生长因子及其研究进展

赵宏,刘昱辉*   

  1. 中国农业科学院生物技术研究所, 北京 100081
  • 收稿日期:2011-01-24 出版日期:2011-08-25 发布日期:2011-03-09
  • 通讯作者: 刘昱辉,副研究员,博士,主要从事植物生物反应器研究。Tel:010-82106122; E-mail:liuyh@mail.caas.net.cn
  • 作者简介:赵宏,硕士研究生,研究方向为植物基因工程。
  • 基金资助:

    国家863计划项目(2007AA100503)资助。

Human Epidermal Growth Factor and Reaserch Progress on it

ZHAO Hong, LIU Yu-hui   

  1. Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  • Received:2011-01-24 Online:2011-08-25 Published:2011-03-09

摘要: 表皮细胞生长因子是人体内一种重要自分泌/旁分泌的生长因子。人表皮细胞生长因子及其受体调控细胞增殖、分化、迁移、生存等与细胞命运密切相关的过程,在细胞发育、伤口愈合、器官发生中发挥重要作用。本文将对人表皮细胞生长因子的合成、分泌、生化特性、分子结构、家族、受体、信号通路、生物学活性、生理功能、应用及制备方法等方面进行综述。

关键词: 人表皮细胞生长因子, 信号通路, 活性, 制备

Abstract: Human epidermal growth factor (hEGF)  is an important autocrine/paracrine factor in human body.  hEGF and its receptor regulate key processes of cell biology, including proliferation, differentiation, migration and survival of cells.  hEGF plays an important role in cell develepmnet, wound healing and organogenesis.  This paper summarizes the hEGF synthesis, secretion, biochemical character, molecular structure, family, receptor, signal pathways, bioactivity, physiological function, applications, and the methods of production.

Key words: human epidermal growth factor (hEGF); , signal pathways, activities, preparation