关键词: 低氧诱导因子, 稳定性调控, 转录活性, 靶向抑制剂, 肿瘤治疗

Abstract: Hypoxia is a common physiological and pathological phenomenon in vivo and a common microenvironment of solid tumors. There are a series of regulation mechanisms in humans and other mammals to deal with hypoxia stress. And hypoxia-inducible factors (HIFs) are the key regulators of these regulation mechanisms, and they are a family of transcription factors involved in cellular hypoxia response. Extensive studies have shown that HIFs are closely related to growth and development of organisms, angiogenesis, erythropoiesis, cell metabolism and autophagy, and occurrence, development, metastasis and invasion, radiochemotherapy resistance of tumor as well as poor prognosis of cancer patients. Therefore, it is of great significance to further strengthen the research on HIFs and their inhibitors for the understanding and treatment of tumors. The progress of protein structure, stability regulation, transcriptional activation regulation and targeted inhibitors of HIFs was reviewed, in order to provide new insights in HIFs targeted tumor therapy and offer references for the research and development of new HIFs inhibitors.

Key words: HIFs, stability regulation, transcriptional activity, targeted inhibitor, tumor therapy