关键词: 免疫疗法, 免疫检查点, CTLA-4, PD-1, PD-L1

Abstract: Immunotherapy which has unique advantages and great potential provides a new approach for the treatment of tumor, and immune checkpoints blocking is an important part of immunotherapy. At present, the blockade of immune checkpoints has made important progress in clinical research. Many domestic and foreign enterprises have developed antibodies targeting immune checkpoints and achieved good clinical effects on specific indications. The action mechanism of cytotoxic T lymphocyte associate protein 4 (CTLA-4), programmed death-1 (PD-1) and its ligand (PD-L1) of immune checkpoints as well as the development status of their antibody drugs in domestic and foreign enterprises were expounded in detail, and the progress on other immune checkpoints was also summarized, in order to provide new ideas for the research of immunotherapy.

Key words: immunotherapy, immune checkpoint, CTLA-4, PD-1, PD-L1