关键词: 肝细胞癌, 循环肿瘤细胞, 生物标记物, 检测

Abstract: Hepatocellular carcinoma (HCC) is one of the high incidence and mortality rates of the malignant tumors in our country. Tumor resection or liver transplantation is the most effective means for treatment the disease. However, the high recurrence and transfer rates after operation influence seriously the prognosis of the patients. Circulating tumor cells (CTCs) in the peripheral blood is the important factor resulting in recurrence and metastasis of liver cancer after operation. In this paper, we reviewed the biomarkers of CTCs, e.g., glypican-3, transferrin receptor, alpha-fetoprotein, α-L-fucosidase, epithelial cell adhesion molecule, golgi protein, des-gamma-carboxy prothrombin, and the specificity and sensitivity for detection of CTCs using these biomarkers. The review was benefited for detecting the early cancer metastases, monitoring the recurrence, evaluating prognosis and choosing specific treatments for the patients with hepatocellular carcinoma.

Key words: hepatocellular carcinoma, circulating tumor cells, biomarkers, detection