线粒体质量控制失衡导致糖尿病肾病肾间质纤维化的研究进展

doi:10.19586/j.2095-2341.2024.0014

生物技术进展 ›› 2024, Vol. 14 ›› Issue (5): 825-831.DOI: 10.19586/j.2095-2341.2024.0014

• 进展评述 • 上一篇

线粒体质量控制失衡导致糖尿病肾病肾间质纤维化的研究进展

赵艺玮¹(), 高甜璐¹, 张佳辉¹, 王钰淇¹, 常盼², 王红²()

^1.西安医学院第二临床医学院麻醉医学系，西安 710038
^2.西安医学院第二附属医院心血管内科，西安 710038

收稿日期:2024-01-26 接受日期:2024-03-27 出版日期:2024-09-25 发布日期:2024-10-22
通讯作者: 王红
作者简介:赵艺玮 E-mail：925917352@qq.com；
基金资助:
国家自然科学基金—大学生创新创业训练计划项目(S202211840083);陕西省教育厅2023年度服务地方专项科学研究计划项目（产业化培育项目）(23JC059)

Research Progress on the Imbalance of Mitochondrial Quality Control Leading to Renal Interstitial Fibrosis in Diabetic Kidney Disease

Yiwei ZHAO¹(), Tianlu GAO¹, Jiahui ZHANG¹, Yuqi WANG¹, Pan CHANG², Hong WANG²()

^1.Department of Anesthesiology，Second Clinical Medical College，Xi'an Medical University，Xi'an 710038，China
^2.Cardiovascular Medicine，Second Affiliated Hospital of Xi'an Medical University，Xi'an 710038，China

Received:2024-01-26 Accepted:2024-03-27 Online:2024-09-25 Published:2024-10-22
Contact: Hong WANG

摘要/Abstract

摘要：

肾间质纤维化是糖尿病肾病（diabetic kidney disease，DKD）的重要病理特征，也是促使其发展为终末期肾病的重要因素，严重威胁糖尿病肾病患者的生命安全。目前，糖尿病肾病的研究已取得较大进展，但线粒体质量控制在其发生、发展过程中的具体机制尚不清楚。真核细胞功能的维持离不开线粒体，而线粒体稳态的维持依赖于线粒体质量控制，包括线粒体生物发生、线粒体动力学、线粒体蛋白稳态以及线粒体自噬等机制。这些机制的缺失可能导致线粒体结构损伤和功能障碍，进而造成细胞死亡与组织损伤。越来越多的证据表明，线粒体质量控制失衡在肾间质纤维化的发生与进展中起到了关键作用。综述了在糖尿病肾病肾间质纤维化中线粒体质量控制的研究进展，以期为糖尿病肾病的治疗提供新的思路，从而提高糖尿病肾病患者的存活率和生活质量。

关键词: 线粒体, 质量控制, 糖尿病肾病, 肾间质纤维化

Abstract:

Renal interstitial fibrosis is an important pathological feature of diabetic kidney disease （diabetic kidney disease，DKD）， and also an important factor to promote its development into end-stage renal disease， which seriously threatens the life safety of patients with diabetic kidney disease. At present， great progress has been made in the research of diabetic kidney mitochondrial disease， but the specific mechanism of mitochondrial quality control in its occurrence and development is still unclear. The maintenance of eukaryotic cell function relies on mitochondria， and the maintenance of mitochondrial homeostasis depends on mitochondrial quality control， including mechanisms such as mitochondrial biogenesis， mitochondrial dynamics， mitochondrial protein homeostasis， and mitochondrial autophagy. The absence of these mechanisms may lead to mitochondrial structural damage and dysfunction， resulting in cell death and tissue damage. More and more evidence suggested that the imbalance of mitochondrial quality control plays a crucial role in the occurrence and progression of renal interstitial fibrosis. This article reviewed the research progress of mitochondrial quality control in renal interstitial fibrosis of diabetic kidney disease， with a view providing new ideas for the treatment of diabetic kidney disease， so as to improve the survival rate and the life quality of patients with diabetic kidney disease.

Key words: mitochondrion, quality control, diabetic kidney disease, renal interstitial fibrosis

中图分类号:

R587.1

赵艺玮, 高甜璐, 张佳辉, 王钰淇, 常盼, 王红. 线粒体质量控制失衡导致糖尿病肾病肾间质纤维化的研究进展[J]. 生物技术进展, 2024, 14(5): 825-831.

Yiwei ZHAO, Tianlu GAO, Jiahui ZHANG, Yuqi WANG, Pan CHANG, Hong WANG. Research Progress on the Imbalance of Mitochondrial Quality Control Leading to Renal Interstitial Fibrosis in Diabetic Kidney Disease[J]. Current Biotechnology, 2024, 14(5): 825-831.

图/表 2

参考文献 54

1	SUN H, SAEEDI P, KARURANGA S, et al.. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J/OL]. Diabetes Res. Clin. Pract., 2022, 183: 109119[2024-03-26]. .
2	PELLE M C, PROVENZANO M, BUSUTTI M, et al.. Up-date on diabetic nephropathy [J/OL]. Life (Basel)., 2022,12(8):1202[2024-01-25]. .
3	ZHANG Y, JIN D, KANG X, et al.. Signaling pathways involved in diabetic renal fibrosis[J/OL]. Front. Cell Dev. Biol., 2021, 9: 696542[2024-03-26]. .
4	MARTÍNEZ-KLIMOVA E, APARICIO-TREJO O E, GÓMEZ-SIERRA T, et al.. Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction[J]. Biofactors, 2020, 46(5): 716-733.
5	AHMAD A A, DRAVES S O, ROSCA M. Mitochondria in diabetic kidney disease[J/OL]. Cells, 2021, 10(11): 2945[2024-03-26]. .
6	BAEK J, LEE Y H, JEONG H Y, et al.. Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease[J]. Kidney Res. Clin. Pract., 2023, 42(5): 546-560.
7	ZHAO M, LI Y, LU C, et al.. PGC1α degradation suppresses mitochondrial biogenesis to confer radiation resistance in glioma[J]. Cancer Res., 2023, 83(7): 1094-1110.
8	TANRIOVER C, COPUR S, UCKU D, et al.. The mitochondrion: a promising target for kidney disease[J/OL]. Pharmaceutics, 2023, 15(2): 570[2024-03-26]. .
9	SHE Y, YU M, WANG L, et al.. Emerging protective actions of PGC-1α in diabetic nephropathy[J/OL]. Oxid. Med. Cell. Longev., 2022, 2022: 6580195[2024-03-26]. .
10	YUAN L, YUAN Y, LIU F, et al.. PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury[J]. Aging (Albany NY), 2021, 13(6): 8421-8439.
11	FONTECHA-BARRIUSO M, LOPEZ-DIAZ A M, GUERRERO-MAUVECIN J, et al.. Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease[J/OL]. Antioxidants (Basel), 2022, 11(7): 1356[2024-03-26]. .
12	QIN X, JIANG M, ZHAO Y, et al.. Berberine protects against diabetic kidney disease via promoting PGC-1α-regulated mitochondrial energy homeostasis[J]. Br. J. Pharmacol., 2020, 177(16): 3646-3661.
13	BIAN C, REN H. Sirtuin family and diabetic kidney disease[J/OL]. Front. Endocrinol. (Lausanne), 2022, 13: 901066[2024-03-26]. .
14	ALA M. Sestrin2 signaling pathway regulates podocyte biology and protects against diabetic nephropathy[J/OL]. J. Diabetes Res., 2023, 2023: 8776878[2024-03-26]. .
15	NAM B Y, JHEE J H, PARK J, et al.. PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis[J/OL]. Cell Death Dis., 2022, 13(1): 31[2024-03-26]. .
16	ZHOU Y, LIU L, JIN B, et al.. Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy[J]. Diabetes, 2023, 72(5): 611-626.
17	CHAN D C. Mitochondrial dynamics and its involvement in disease[J]. Annu. Rev. Pathol., 2020, 15: 235-259.
18	NYENHUIS S B, WU X, STRUB M P, et al.. OPA1 helical structures give perspective to mitochondrial dysfunction[J]. Nature, 2023, 620(7976): 1109-1116.
19	QIN L, XI S. The role of mitochondrial fission proteins in mitochondrial dynamics in kidney disease[J/OL]. Int. J. Mol. Sci., 2022, 23(23): 14725[2024-03-26]. .
20	CHENG Y H, YAO C A, YANG C C, et al.. Sodium thiosulfate through preserving mitochondrial dynamics ameliorates oxidative stress induced renal apoptosis and ferroptosis in 5/6 nephrectomized rats with chronic kidney diseases[J/OL]. PLoS One, 2023, 18(2): e0277652[2024-03-26]. .
21	POOLSRI W, NOITEM R, JUTABHA P, et al.. Discovery of a Chalcone derivative as an anti-fibrotic agent targeting transforming growth factor-β1 signaling: potential therapy of renal fibrosis[J/OL]. Biomed. Pharmacother., 2023, 165: 115098[2024-03-26]. .
22	WANG Y, LU M, XIONG L, et al.. Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis[J/OL]. Cell Death Dis., 2020, 11(1): 29[2024-03-26]. .
23	GALVAN D L, MISE K, DANESH F R. Mitochondrial regulation of diabetic kidney disease[J/OL]. Front. Med. (Lausanne), 2021, 8: 745279[2024-03-26]. .
24	关毅鸣,王丽妍,刘文虎.线粒体功能及其与急性肾损伤和糖尿病肾病的关系[J].医学研究杂志,2020,49(7):5-8.
	GUAN Y M, WANG L Y, LIU W H. Mitochondrial function and its relationship with acute renal injury and diabetes nephropathy[J]. J. Med. Res., 2020,49(7):5-8.
25	NARONGKIATIKHUN P, CHATTIPAKORN S C, CHATTIPAKORN N. Mitochondrial dynamics and diabetic kidney disease: missing pieces for the puzzle of therapeutic approaches[J]. J. Cell. Mol. Med., 2022, 26(2): 249-273.
26	ZHONG Y, JIN R, LUO R, et al.. Diosgenin targets CaMKK2 to alleviate type II diabetic nephropathy through improving autophagy, mitophagy and mitochondrial dynamics[J/OL]. Nutrients, 2023, 15(16): 3554[2024-03-26]. .
27	FLEMMING N, PERNOUD L, FORBES J, et al.. Mitochondrial dysfunction in individuals with diabetic kidney disease: a systematic review[J/OL]. Cells, 2022, 11(16): 2481[2024-03-26]. .
28	JIANG N, ZHAO H, HAN Y, et al.. HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics[J/OL]. Cell Prolif., 2020, 53(11): e12909[2024-03-26]. .
29	WACHOSKI-DARK E, ZHAO T, KHAN A, et al.. Mitochondrial protein homeostasis and cardiomyopathy[J/OL]. Int. J. Mol. Sci., 2022, 23(6): 3353[2024-03-26]. .
30	ARRIETA A, BLACKWOOD E A, STAUFFER W T, et al.. Integrating ER and mitochondrial proteostasis in the healthy and diseased heart[J/OL]. Front. Cardiovasc. Med., 2020, 6: 193[2024-03-26]. .
31	DESHW‍AL S, FIEDLER K U, LANGER T. Mitochondrial proteases: multifaceted regulators of mitochondrial plasticity[J]. Annu. Rev. Biochem., 2020, 89: 501-528.
32	TODOSENKO N, KHAZIAKHMATOVA O, MALASHCHENKO V, et al.. Mitochondrial dysfunction associated with mtDNA in metabolic syndrome and obesity[J/OL]. Int. J. Mol. Sci., 2023, 24(15): 12012[2024-03-26]. .
33	SUN C L, VAN GILST M, CROWDER C M. Hypoxia-induced mitochondrial stress granules[J/OL]. Cell Death Dis., 2023, 14(7): 448[2024-03-26]. .
34	CATRINA S B, ZHENG X. Hypoxia and hypoxia-inducible factors in diabetes and its complications[J]. Diabetologia, 2021, 64(4): 709-716.
35	BAI M, WU M, JIANG M, et al.. LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease[J/OL]. EMBO Mol. Med., 2023, 15(2): e16581[2024-03-26]. .
36	ZHANG Y, WEN P, LUO J, et al.. Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis[J/OL]. Cell Death Dis., 2021, 12(9): 847[2024-03-26]. .
37	LI R, WANG Z, WANG Y, et al.. SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1[J]. J. Cell. Physiol., 2023, 238(9): 2090-2102.
38	JIAN Y, YANG Y, CHENG L, et al.. Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1[J/OL]. Cell Prolif., 2023, 56(2): e13362[2024-03-26]. .
39	ONISHI M, YAMANO K, SATO M, et al.. Molecular mechanisms and physiological functions of mitophagy[J/OL]. EMBO J., 2021, 40(3): e104705[2024-03-26]. .
40	YAN C, GONG L, CHEN L, et al.. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis[J]. Autophagy, 2020, 16(3): 419-434.
41	SHAN Z, FA W H, TIAN C R, et al.. Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment[J]. Aging, 2022, 14(6): 2902-2919.
42	WANG D, KANG L, CHEN C A, et al.. Loss of legumain induces premature senescence and mediates aging-related renal fibrosis[J/OL]. Aging Cell, 2022, 21(3): e13574[2024-03-26]. .
43	JIN L, YU B, LIU G, et al.. Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis[J/OL]. FASEB J., 2022, 36(6): e22342[2024-03-26]. .
44	YOON Y M, GO G, YOON S, et al.. Melatonin treatment improves renal fibrosis via miR-4516/SIAH3/PINK1 axis[J/OL]. Cells, 2021, 10(7): 1682[2024-03-26]. .
45	LIU T, YANG Q, ZHANG X, et al.. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis[J/OL]. Life Sci., 2020, 257: 118116[2024-03-26]. .
46	LIU L, BAI F, SONG H, et al.. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy[J/OL]. Redox Biol., 2022, 50: 102260 [2024-03-26]. .
47	WANG X, SONG M, LI X, et al.. CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease[J/OL]. Am. J. Physiol. Cell Physiol., 2023, 325(2):C538-C549[2024-03-26]. .
48	HAN Y C, TANG S Q, LIU Y T, et al.. AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice[J/OL]. Cell Death Dis., 2021, 12(10): 925[2024-03-26]. .
49	HUANG C, YI H, SHI Y, et al.. KCa3.1 mediates dysregulation of mitochondrial quality control in diabetic kidney disease[J/OL]. Front. Cell Dev. Biol., 2021, 9: 573814[2024-03-26]. .
50	JPARK S, KIM Y, LI C, et al.. Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome[J/OL]. Proc. Natl. Acad. Sci. USA, 2022, 119(35): e2116505119[2024-03-26]. .
51	LIU Z, NAN P, GONG Y, et al.. Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy[J/OL]. Biomed. Pharmacother., 2023, 164: 114897[2024-03-26]. .
52	INAGI R. Organelle stress and metabolic derangement in kidney disease[J/OL]. Int. J. Mol. Sci., 2022, 23(3): 1723[2024-03-26]. .
53	MAO H, CHEN W, CHEN L, et al.. Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases[J/OL]. Biochem. Pharmacol., 2022, 199: 115011[2024-03-26]. .
54	XUE M, FANG T, SUN H, et al.. PACS-2 attenuates diabetic kidney disease via the enhancement of mitochondria-associated endoplasmic reticulum membrane formation[J/OL]. Cell Death Dis., 2021, 12(12): 1107[2024-03-26]. .

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线粒体质量控制失衡导致糖尿病肾病肾间质纤维化的研究进展

Research Progress on the Imbalance of Mitochondrial Quality Control Leading to Renal Interstitial Fibrosis in Diabetic Kidney Disease

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