关键词: 肉苁蓉, 肉苁蓉苯乙醇苷, 肿瘤, 细胞增殖与凋亡

Abstract:

Malignant tumors have always been recognized as a major public health problem that threaten human health in the world. With the acceleration of the social aging and the influence of some other factors， the incidence of various malignant tumors has gradually shown an upward trend， and most of the tumors have entered the advanced stage when they were found， with rapid disease progression and poor prognosis. Although new therapies for tumor treatment have emerged in recent years and many of them have encouraging effects， there are still problems such as large side effects and ineffectiveness in some patients. Therefore， it is of great clinical significance to explore and develop new drug candidate compounds with strong anti-tumor effect， small side effects and not easy to drug resistance， especially bioactive molecules from Chinese herbal medicine. Cistanche deprived phenylethanol glycosides （CPhGs） is a class of active ingredients contained in the Chinese herb Cistanche deserticola. Recent studies have shown that it has anti-tumor， immunomodulatory， antioxidant and other biological functions， and has good application prospects. Here， the research results and current scientific understanding of the anti-tumor effect and mechanism of phenylethanoid glycosides in Cistanche deserticola were briefly reviewed in order to promote the further research and clinical application of Cistanche deserticola and its phenylethanoid glycosides extracts.

Key words: Cistanche, Cistanche deprived phenylethanol glycosides, tumor, cell proliferation and apoptosis