微量元素硒在对抗COVID-19中的作用研究进展

doi:10.19586/j.2095-2341.2022.0168

生物技术进展 ›› 2023, Vol. 13 ›› Issue (1): 72-76.DOI: 10.19586/j.2095-2341.2022.0168

微量元素硒在对抗COVID-19中的作用研究进展

高敏宜¹(), 徐笑¹(), 高已雯¹(), 陈鹰², 马钲斐³, 袁林喜¹()

^1.西交利物浦大学理学院健康与环境科学系，江苏苏州 215123
^2.西交利物浦大学药学院，江苏苏州 215123
^3.西英格兰大学，英国布里斯托 BS16 1QY

收稿日期:2022-10-11 接受日期:2022-11-14 出版日期:2023-01-25 发布日期:2023-02-07
通讯作者: 袁林喜
作者简介:高敏宜 E-mail: Minyi.Kau19@student.xjtlu.edu.cn
徐笑 E-mail: Xiao.Xu19@student.xjtlu.edu.cn
高已雯 E-mail: Yiwen.Gao20@student.xjtlu.edu.cn；第一联系人：（高敏宜、徐笑与高已雯并列第一作者）
基金资助:
西交利物浦大学大学生暑期研究奖学金项目(SURF 2022153)

Narrative Review on the Roles of Selenium Against COVID-19

Minyi KAU¹(), Xiao XU¹(), Yiwen GAO¹(), Ying CHEN², Zhengfei MA³, Linxi YUAN¹()

^1.Department of Health and Environmental Sciences，School of Science，Xi'an Jiaotong-Liverpool University，Jiangsu Suzhou 215123，China
^2.Wisdom Lake Academy of Pharmacy，Xi'an Jiaotong-Liverpool University，Jiangsu Suzhou 215123，China
^3.University of the West of England，Bristol BS16 1QY，UK

Received:2022-10-11 Accepted:2022-11-14 Online:2023-01-25 Published:2023-02-07
Contact: Linxi YUAN

摘要/Abstract

摘要：

自新型冠状病毒肺炎（corona virus disease 2019，COVID-19）疫情爆发以来，严重急性呼吸综合征冠状病毒2（severe acute respiratory syndrome-coronavirus 2， SARS-CoV-2）引起的各类临床表现和后续并发症受到了广泛关注。有研究发现，COVID-19死亡率具有地域差异性，中度或重度缺硒地区感染人群常常具有更高的死亡率，因此硒可能在对抗COVID-19中具有一定的作用。总结了硒缺乏COVID-19患者的临床表现、硒对抗COVID-19的临床效应、以及硒对抗COVID-19的作用机制等方面的研究进展。从目前的研究结果来看，硒在应对感染SARS-CoV-2以及避免过激免疫反应导致的细胞因子风暴过程中具有积极作用，但仍然缺乏临床试验研究证据。

关键词: COVID-19, 硒, 硒缺乏, 硒蛋白, 细胞因子风暴

Abstract:

Since the outbreak of corona virus disease 2019 （COVID-19） in 2019， the symptoms and complications caused by severe acute respiratory syndrome-coronavirus 2 （SARS-CoV-2） have received much attention. Some studies have found that the case fatality rate varies among the different areas， in which moderate or severe selenium （Se） deficiency areas had higher case fatality rates， indicating Se might play some roles during development of COVID-19. The symptoms of Se deficient COVID-19 patients， the use of Se supplements in COVID-19 treatment and the possible mechanism of Se against COVID-19 were summarized through a systematic literature review. From current outcomes， Se could play positive roles in adjusting the immune system and relieving inflammation， which could help avoid the cytokine storm， but need more clinical studies to verify.

Key words: COVID-19, selenium, selenium deficiency, selenoproteins, cytokine storm

中图分类号:

O613.52

高敏宜, 徐笑, 高已雯, 陈鹰, 马钲斐, 袁林喜. 微量元素硒在对抗COVID-19中的作用研究进展[J]. 生物技术进展, 2023, 13(1): 72-76.

Minyi KAU, Xiao XU, Yiwen GAO, Ying CHEN, Zhengfei MA, Linxi YUAN. Narrative Review on the Roles of Selenium Against COVID-19[J]. Current Biotechnology, 2023, 13(1): 72-76.

参考文献 29

1	World Health Organization. Weekly epidemiological update on COVID-19-10 August 2022[EB/OL].[2022-08-10]. .
2	JIANG F, DENG L, ZHANG L, et al.. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)[J]. J. Gen. Intern. Med., 2020, 35(5): 1545-1549.
3	ZHOU P, YANG X L, WANG X G, et al.. A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature, 2020, 579: 270-273.
4	HOFFMANN M, KLEINE-WEBER H, SCHROEDER S, et al.. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor[J]. Cell, 2020, 181(2): 271-280.
5	GHEBLAWI M, WANG K, VIVEIROS A, et al.. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2[J]. Circ. Res., 2020, 126(10): 1456-1474.
6	ZHOU Y, FU B, ZHENG X, et al.. Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients[J]. Natl. Sci. Rev., 2020, 7(6): 998-1002.
7	HUANG C, WANG Y, LI X, et al.. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395: 497-506.
8	MUSTAFA M I, ABDELMONEIM A H, MAHMOUD E M, et al.. Cytokine storm in COVID-19 patients, its impact on organs and potential treatment by QTY code-designed detergent-free chemokine receptors[J/OL]. Mediat. Inflamm., 2020,2020: 8198963[2022-08-14]. .
9	RAYMAN M. The importance of selenium to human health[J]. Lancet, 2000, 356(9225): 233-241.
10	CHENG Z, ZHI X, SUN G, et al.. Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines[J]. J. Med. Virol., 2016, 88: 653-663.
11	STEINBRENNER H, AL-QURAISHY S, DKHIL M A, et al.. Dietary selenium in adjuvant therapy of viral and bacterial infections[J]. Adv. Nutr., 2015, 6(1): 73-82.
12	ZHANG H Y, ZHANG A R, LU Q B, et al.. Association between fatality rate of COVID-19 and selenium deficiency in China[J/OL]. BMC Infect. Dis., 2021, 21: 452[2022-07-31]. .
13	CHEN Y, MA Z F, YU D, et al.. Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA[J/OL]. Environ. Geochem. Health., 2022, 44: 4423-4436.
14	SKESTERS A, KUSTOVS D, LECE A, et al.. Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery[J]. Inflammopharmacology, 2022, 30: 499-503.
15	EROL S A, POLAT N, AKDAS S, et al.. Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection[J]. J. Med. Virol., 2021, 93: 5438-5445.
16	MAJEED M, NAGABHUSHANAM K, PRAKASAN P, et al.. Can selenium reduce the susceptibility and severity of SARS-CoV-2?—a comprehensive review[J/OL]. Int. J. Mol. Sci., 2022, 23: 4809[2022-07-31]. .
17	IM J, JE Y, BAEK J, et al.. Nutritional status of patients with COVID-19[J]. Int. J. Infect. Dis., 2020, 100: 390-393.
18	MOGHADDAM A, HELLER R A, SUN Q, et al.. Selenium deficiency is associated with mortality risk from COVID-19[J/OL]. Nutrients, 2020, 12(7): 2098[2022-07-29]. .
19	OZDEMIR K, SARUHAN E, BENLI T, et al.. Comparison of trace element (selenium, iron), electrolyte (calcium, sodium), and physical activity levels in COVID-19 patients before and after the treatment[J/OL]. J. Trace. Elem. Med. Biol., 2022, 73: 127015[2022-07-29]. .
20	NOTZ Q, HERRMANN J, SCHLESINGER T, et al.. Clinical significance of micronutrient supplementation in critically Ill COVID-19 patients with severe ARDS[J/OL]. Nutrients, 2021, 13: 2113[2022-07-23]. .
21	RAKIB A, NAIN Z, SAMI S, et al.. A molecular modelling approach for identifying antiviral selenium-containing heterocyclic compounds that inhibit the main protease of SARS-CoV-2: an in silico investigation[J]. Brief. Bioinform., 2021, 22(2): 1476-1498.
22	DEMIRCAN K, CHILLON T, SUN Q, et al.. Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status[J/OL]. Redox Biol., 2022, 50: 102242[2022-07-29]. .
23	SEALE L A, TORRES D J, BERRY M J, et al.. A role for selenium-dependent GPX1 in SARS-CoV-2 virulence[J]. Am. J. Clin. Nutr., 2020, 112(2): 447-448.
24	MAL'TSEVA V N, GOLTYAEV M V, TUROVSKY E A, et al.. Immunomodulatory and anti-inflammatory properties of selenium-containing agents: their role in the regulation of defense mechanisms against COVID-19[J/OL]. Int. J. Mol. Sci., 2022, 23(4): 2360[2022-07-23]. .
25	WANG Y, HUANG J, SUN Y, et al.. SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis[J/OL]. Food Chem. Toxicol., 2021, 153: 112286[2022-08-03]. .
26	BECKER N P, MARTITZ J, RENKO K, et al.. Hypoxia reduces and redirects selenoprotein biosynthesis[J]. Metallomics, 2014, 6(5): 1079-1086.
27	MARTITZ J, BECKER N P, RENKO K, et al.. Gene-specific regulation of hepatic selenoprotein expression by interleukin-6[J]. Metallomics, 2015, 7(11): 1515-152.
28	GORINI F, SABATINO L, COI A, et al.. Thyroid dysfunction and COVID-19: the emerging role of selenium in this intermingled relationship[J/OL]. Int. J. Environ., 2022, 19(11): 6912[2022-08-02]. .
29	PECORARO L, MARTINI L, SALVOTTINI C, et al.. The potential role of zinc, magnesium and selenium against COVID-19: a pragmatic review[J]. Child Adolescent Obesity, 2021, 4(1): 127-130.

[1]	臧华伟, 张泽洲, 龙泽东, 施文尧, 尹雪斌, 刘永贤, 袁林喜. 中国硒资源利用中若干关键科学问题的探讨[J]. 生物技术进展, 2021, 11(4): 542-549.
[2]	孙卉,张春义,姜凌. 硒与叶酸在抗病毒治疗中的作用及其在植物中的应用前景分析[J]. 生物技术进展, 2020, 10(5): 487-494.
[3]	王锐,余涛,曾庆良,杨忠芳. 我国主要农耕区土壤硒含量分布特征、来源及影响因素[J]. 生物技术进展, 2017, 7(5): 359-366.
[4]	秦海波,朱建明. 中国典型高硒区硒的环境地球化学研究进展[J]. 生物技术进展, 2017, 7(5): 367-373.
[5]	梁东丽,彭琴,崔泽玮,王丹,李哲,黄杰,QUANG Toan Dinh. 土壤中硒的形态转化及其对有效性的影响研究进展[J]. 生物技术进展, 2017, 7(5): 374-380.
[6]	李海蓉,杨林生,谭见安,王五一,侯少范,李永华,虞江萍,韦炳干. 我国地理环境硒缺乏与健康研究进展[J]. 生物技术进展, 2017, 7(5): 381-386.
[7]	孙国新,李媛,李刚,陈正4,朱永官,. 我国土壤低硒带的气候成因研究[J]. 生物技术进展, 2017, 7(5): 387-394.
[8]	袁林喜,张影. 硒超积累植物壶瓶碎米荠的根际微生物特征研究[J]. 生物技术进展, 2017, 7(5): 395-401.
[9]	龙云川,陈轩,周少奇,. 高产铁载体根际菌的筛选鉴定及硒活化特性评价[J]. 生物技术进展, 2017, 7(5): 402-408.
[10]	张泽洲,朱元元,李梦,李单,侯遇珠,袁林喜,尹雪斌. 生物样品中硒的形态分析方法研究进展[J]. 生物技术进展, 2017, 7(5): 409-414.
[11]	戴志华,高菲,赵敏,韩丹,王兆双,涂书新,. 作物对硒的吸收利用及合理施用硒肥[J]. 生物技术进展, 2017, 7(5): 415-420.
[12]	陈锦平,刘永贤,曾成城,潘丽萍,鹿士杨,兰秀,黄雁飞,梁潘霞,江泽普,邢颖,廖青,黄太庆. 植物对土壤硒的吸收转化研究进展[J]. 生物技术进展, 2017, 7(5): 421-427.
[13]	吴信,孟田田,万丹,谢春艳,印遇龙,. 硒在畜禽养殖中的应用研究进展[J]. 生物技术进展, 2017, 7(5): 428-432.
[14]	孙发宇,杨亮,李磊,袁林喜,尹雪斌,杨光,4,李韬. 小麦硒强化研究进展[J]. 生物技术进展, 2017, 7(5): 433-438.
[15]	马丽佳, 张泽洲, 袁林喜, 尹雪斌. 硒生物营养强化小麦在发芽过程中的生理特征研究[J]. 生物技术进展, 2017, 7(5): 439-444.

微量元素硒在对抗COVID-19中的作用研究进展

Narrative Review on the Roles of Selenium Against COVID-19

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 29

相关文章 15

编辑推荐

Metrics

本文评价