关键词: 环境硒, 地域分异, 克山病, 大骨节病, 低硒带, 阈值, 砷中毒

Abstract: The range and degree of selenium (Se) deficient in geographical environment of our country is serious. This paper reviewed the main progress on the Se deficiency in environment and its impacts on human health in the last 50 years of China. The main topics were the relationship between the regional differentiation of environmental Se and Keshan Disease(KSD) and Kashin-Beck Disease(KBD), the occurrence mechanism of low Se environment and its improvements, and the prevention and treatment of endemic arsenism with Se supplementation. Based on the progress, the future studies of environmental Se and human health was proposed in order to provide a scientific basis for the development and utilization of Se resources and the research on baseline nutrition level of Se in different population.

Key words: environmental selenium, regional differentiation, Keshan Disease, Kashin-Beck Disease, low-selenium belt, threshold value, endemic arsenism