关键词: 硒, 胰腺癌, 观察流行病学, meta分析

Abstract: Globally, pancreatic cancer causes more than a quarter of a million deaths annually. Although some risk factors have been identified, the association between diet or individual nutrients and pancreatic cancer risk remains unclear. The association between selenium (Se) intake and the risk of pancreatic cancer has been examined by a few observational studies, but remains controversial because of inconsistent results. Therefore, we aimed to conduct this meta-analysis to investigate the association between Se intake and risk of pancreatic cancer. PubMed and Embase databases were searched for observational studies up to May 2017. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effect model. Final analysis included three cohort studies and three case-control studies. The combined RR of pancreatic cancer for Se intake was 0.76 with a 95% CI of 0.62~0.93. There were no evidence of heterogeneity (P=0.66,I2=0%) and publication bias (Begg′s test: P>0.1; Egger′s test: P>0.1). This meta-analysis provided evidence of a significant inverse association between Se intake and pancreatic cancer.

Key words: selenium, pancreatic cancer, observational study, meta-analysis