关键词: 硒, 内自生纳米硒粒子, 多重毒理效应, 超大剂量, 肿瘤耐受性

Abstract: As an important nutrient element that participate in the activities of life, selenium (Se) has general prevention and anti-cancer effects. So far, variety opinions were concluded on Se anti-tumor mechanism. This paper reviewed the progress on anti-tumor effects and mechanisms of Se, and highlighted the latest study founding, that sodium selenite exposure could occur selenite reduction to elemental Se, and combined with intracellular protein for self-assembly of Se nanoparticles within the tumor cells. The results well explained the multiple toxicology effect of Se with large dose and the enhanced inhibition effect to radiation and chemotherapy tolerance tumors. The further study of the Se nanoparticles in tumor cells/tissues will reveal the underlying anti-tumor mechanisms of Se, and form an unified understanding of Se anti-tumor mechanisms.

Key words: selenium, endogenous selenium nanoparticles, multiple toxicology effects, ultra high dose, tumor tolerance