关键词: 骨肉瘤, P53, 凋亡, 铁死亡, 自噬

Abstract:

Osteosarcoma （OS） is the most common primary bone malignant tumor，with strong local invasion， metastasis， and a high risk of recurrence， which mainly affects the health of children and adolescents. At present， chemotherapy and surgery are the main methods for treating OS， but the efficacy is not significant， and immune checkpoint inhibitors have poor clinical application efficacy， requiring new therapeutic targets. As a classic tumor suppressor gene， P53 gene participates in many biological processes such as cell cycle regulation， DNA repair and cell death. The mutation of P53 is widespread in OS and closely related to tumor aggressiveness and prognosis. In addition to its traditional role in apoptosis， P53 also plays an important role in non-classical cell death pathways such as autophagy and ferroptosis， which makes it a key target for OS treatment. This article reviewed the role of P53 in osteosarcoma， with a focus on exploring the regulatory mechanisms of P53 in apoptosis， autophagy and ferroptosis， as well as its research progress in OS. The article aimed to provide new theoretical basis and guidance for future therapeutic targets and strategies for OS.

Key words: osteosarcoma, P53, apoptosis, iron death, autophagy