1 |
SCHIER A C, TAATJES D J. Structure and mechanism of the RNA polymerase Ⅱ transcription machinery[J]. Genes Dev., 2020, 34(7-8): 465-488.
|
2 |
CORE L, ADELMAN K. Promoter-proximal pausing of RNA polymerase Ⅱ: A nexus of gene regulation[J]. Genes Dev., 2019, 33(15-16): 960-982.
|
3 |
PROUDFOOT N J. Transcriptional termination in mammals: Stopping the RNA polymerase Ⅱ juggernaut[J/OL]. Science, 2016, 352(6291): aad9926[2022-06-25]. .
|
4 |
ADELMAN K, LIS J T. Promoter-proximal pausing of RNA polymerase Ⅱ: emerging roles in metazoans[J]. Nat. Rev. Genet., 2012, 13(10): 720-731.
|
5 |
YAMAGUCHI Y, SHIBATA H, HANDA H. Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond[J]. Biochim. Biophys. Acta, 2013, 1829(1): 98-104.
|
6 |
VOS S M, FARNUNG L, URLAUB H, et al.. Structure of paused transcription complex Pol Ⅱ-DSIF-NELF[J]. Nature, 2018, 560(7720): 601-606.
|
7 |
AOI Y, SMITH E R, SHAH A P, et al.. NELF Regulates a promoter-proximal step distinct from RNA Pol Ⅱ pause-release[J]. Mol. Cell, 2020, 78(2): 261-274.
|
8 |
CHENG B, LI T, RAHL P B, et al.. Functional association of Gdown1 with RNA polymerase Ⅱ poised on human genes[J]. Mol Cell, 2012, 45(1): 38-50.
|
9 |
LEE C, LI X, HECHMER A, et al.. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila[J]. Mol. Cell Biol., 2008, 28(10): 3290-300.
|
10 |
CHEN F X, WOODFIN A R, GARDINI A, et al.. PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase Ⅱ[J]. Cell, 2015, 162(5): 1003-1015.
|
11 |
YU M, YANG W, NI T, et al.. RNA polymerase Ⅱ-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase Ⅱ[J]. Science, 2015, 350(6266): 1383-1386.
|
12 |
FANT C B, LEVANDOWSKI C B, GUPTA K, et al.. TFⅡD Enables RNA polymerase Ⅱ promoter-proximal pausing[J]. Mol. Cell, 2020, 78(4): 785-793.
|
13 |
CHEN F X, SMITH E R, SHILATIFARD A. Born to run: control of transcription elongation by RNA polymerase Ⅱ[J]. Nat. Rev. Mol. Cell Biol., 2018, 19(7): 464-478.
|
14 |
LI Y, LIU M, CHEN L F, et al.. P-TEFb: finding its ways to release promoter-proximally paused RNA polymerase Ⅱ[J]. Transcription, 2018, 9(2): 88-94.
|
15 |
JI X, ZHOU Y, PANDIT S, et al.. SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase[J]. Cell, 2013, 153(4): 855-868.
|
16 |
CALO E, FLYNN R A, MARTIN L, et al.. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing[J]. Nature, 2015, 518(7538): 249-253.
|
17 |
KANNO T, KANNO Y, LEROY G, et al.. BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones[J]. Nat. Struct. Mol. Biol., 2014, 21(12): 1047-1057.
|
18 |
KOMARNITSKY P, CHO E J, BURATOWSKI S. Different phosphorylated forms of RNA polymerase Ⅱ and associated mRNA processing factors during transcription[J]. Genes Dev., 2000, 14(19): 2452-2460.
|
19 |
ADELMAN K, MARR M T, WERNER J, et al.. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFⅡS[J]. Mol. Cell, 2005, 17(1): 103-112.
|
20 |
YADAV D, GHOSH K, BASU S, et al.. Multivalent role of human TFⅡD in recruiting elongation components at the promoter-proximal region for transcriptional control[J]. Cell Rep., 2019, 26(5): 1303-1317.
|
21 |
RAHL P B, LIN C Y, SEILA A C, et al.. c-Myc regulates transcriptional pause release[J]. Cell, 2010, 141(3): 432-445.
|
22 |
STEINPARZER I, SEDLYAROV V, RUBIN J D, et al.. transcriptional responses to IFN-gamma require mediator kinase-dependent pause release and mechanistically distinct CDK8 and CDK19 functions[J]. Mol. Cell, 2019, 76(3): 485-499.
|
23 |
DONNER A J, EBMEIER C C, TAATJES D J, et al.. CDK8 is a positive regulator of transcriptional elongation within the serum response network[J]. Nat. Struct. Mol. Biol., 2010, 17(2): 194-201.
|
24 |
MCNAMARA R P, REEDER J E, MCMILLAN E A, et al.. KAP1 recruitment of the 7SK snRNP complex to promoters enables transcription elongation by RNA polymerase Ⅱ[J]. Mol. Cell, 2016, 61(1): 39-53.
|
25 |
BARBORIC M, NISSEN R M, KANAZAWA S, et al.. NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase Ⅱ[J]. Mol. Cell, 2001, 8(2): 327-337.
|
26 |
EBERHARDY S R, FARNHAM P J. c-Myc mediates activation of the cad promoter via a post-RNA polymerase Ⅱ recruitment mechanism[J]. J. Biol. Chem., 2001, 276(51): 48562-48571.
|
27 |
LUECKE H F, YAMAMOTO K R. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression[J]. Genes Dev., 2005, 19(9): 1116-1127.
|
28 |
OVEN I, BRDICKOVA N, KOHOUTEK J, et al.. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells[J]. Mol. Cell Biol., 2007, 27(24): 8815-8823.
|
29 |
GILMOUR D S, LIS J T. RNA polymerase Ⅱ interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells[J]. Mol Cell Biol, 1986, 6(11): 3984-3989.
|
30 |
ZEITLINGER J, STARK A, KELLIS M, et al.. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo[J]. Nat. Genet., 2007, 39(12): 1512-1516.
|
31 |
SHAO W, ALCANTARA S G, ZEITLINGER J. Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing[J/OL]. Elife, 2019, 8:e41461[2022-06-25]. .
|
32 |
CHEN K, JOHNSTON J, SHAO W, et al.. A global change in RNA polymerase Ⅱ pausing during the Drosophila midblastula transition [J/OL]. Elife, 2013, 2: e00861[2022-06-25]. .
|
33 |
BOETTIGER A N, LEVINE M. Synchronous and stochastic patterns of gene activation in the Drosophila embryo[J]. Science, 2009, 325(5939): 471-473.
|
34 |
JENNINGS B H, SHAH S, YAMAGUCHI Y, et al.. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila [J]. Curr. Biol., 2004, 14(18): 1680-1684.
|
35 |
WANG X, HANG S, PRAZAK L, et al.. NELF potentiates gene transcription in the Drosophila embryo[J/OL]. PLoS ONE, 2010, 5(7): e11498[2022-06-15]. .
|
36 |
AMLEH A, NAIR S J, SUN J, et al.. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis[J/OL]. PLoS ONE, 2009, 4(4): e5034[2022-06-25]. .
|
37 |
LAGHA M, BOTHMA J P, ESPOSITO E, et al.. Paused Pol Ⅱ coordinates tissue morphogenesis in the Drosophila embryo[J]. Cell, 2013, 153(5): 976-987.
|
38 |
LIU X, GOGATE A A, TASTEMEL M, et al.. Dynamic change of transcription pausing through modulating NELF protein stability regulates granulocytic differentiation[J]. Blood Adv., 2017, 1(18): 1358-1367.
|
39 |
GUO S, YAMAGUCHI Y, SCHILBACH S, et al.. A regulator of transcriptional elongation controls vertebrate neuronal development[J]. Nature, 2000, 408(6810): 366-369.
|
40 |
GATES L A, SHI J, ROHIRA A D, et al.. Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation[J]. J. Biol. Chem., 2017, 292(35): 14456-14472.
|
41 |
ETCHEGARAY J P, ZHONG L, LI C, et al.. The histone deacetylase SIRT6 restrains transcription elongation via promoter-proximal pausing[J]. Mol. Cell, 2019, 75(4): 683-699.
|
42 |
VAID R, WEN J, MANNERVIK M. Release of promoter-proximal paused Pol Ⅱ in response to histone deacetylase inhibition[J]. Nucl. Acids Res., 2020, 48(9): 4877-4890.
|
43 |
HUANG K L, JEE D, STEIN C B, et al.. Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination[J]. Mol. Cell, 2020, 80(2): 345-358.
|
44 |
SHRESTHA P, XIAO S, DHAKAL S, et al.. Nascent RNA transcripts facilitate the formation of G-quadruplexes[J]. Nucl. Acids Res., 2014, 42(11): 7236-7346.
|
45 |
CHEN L, CHEN J Y, ZHANG X, et al.. R-ChIP using inactive RNase H reveals dynamic coupling of r-loops with transcriptional pausing at gene promoters[J]. Mol. Cell, 2017, 68(4): 745-757.
|
46 |
ZHANG X, CHIANG H C, WANG Y, et al.. Attenuation of RNA polymerase Ⅱ pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis[J/OL]. Nat. Commun., 2017, 8: 15908 [2022-06-15]. .
|
47 |
CHEN L, CHEN J Y, HUANG Y J, et al.. The augmented R-Loop Is a unifying mechanism for myelodysplastic syndromes induced by high-risk splicing factor mutations[J]. Mol. Cell, 2018, 69(3): 412-425.
|
48 |
JAUREGUI-LOZANO J, ESCOBEDO S, EASTON A, et al.. Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging[J/OL]. Aging Cell, 2022, 21(2): e13554 [2022-06-15]. .
|
49 |
ALECKI C, CHIWARA V, SANZ L A, et al.. RNA-DNA strand exchange by the Drosophila polycomb complex PRC2[J/OL]. Nat. Commun., 2020, 11(1): 1781 [2022-06-15]. .
|