关键词: 肌肉生长抑制素, 肉牛育种, 肌肉发育, 遗传效应

Abstract: The myostatin (MSTN) gene mainly expresses and participates in the regulation of skeletal muscle growth and development. The MSTN gene not only has strong evolutionary conservation, but also has more mutation polymorphisms. In several cattle breeding, kinds of sense mutations at different location of the MSTN have been clarified. All of the sense MSTN mutations resulted in hypertrophic skeletal muscles, which the mutant cattle have the double muscle phenotype, and increase the growth and meat yield. Simultaneously, some of the mutant cattle arise varieties of negative effects. This review focused on the mutation types of MSTN gene, the mutated genetic effects as well as the possible application in beef cattle breeding. The paper would provide data for the research on improvement and breeding of local beef cattle in China.

Key words: myostatin, beef cattle breeding, muscle development, genetic effect