生物技术进展 ›› 2014, Vol. 4 ›› Issue (3): 182-185.DOI: 10.3969/j.issn.2095-2341.2014.03.06

• 进展评述 • 上一篇    下一篇

化学发光检测试剂鲁米诺的安全使用策略

刘晓志,赵伟,常亮,高健*   

  1. 华北制药集团新药研究开发有限责任公司, 抗体药物研制国家重点实验室, 石家庄 050015
  • 收稿日期:2014-02-10 出版日期:2014-05-25 发布日期:2014-03-31
  • 通讯作者: 高健,高级工程师,主要从事蛋白药物研发。E-mail:gaojian3993@aliyun.com
  • 作者简介:刘晓志,高级工程师,博士,主要从事蛋白药物研发。E-mail:13073182298@163.com。
  • 基金资助:

    国家科技重大专项(2012ZX10001008-015;2012ZX09101313);国家科技支撑计划项目(2012AA02A701)资助。

The Safe Use of a Chemiluminescence Detection Reagent Luminol

LIU Xiao-zhi, ZHAO Wei, CHANG Liang, GAO Jian   

  1. State Key Laboratory of Antibody Research and Development; New Drug Research and Development Company Ltd., North China Pharmaceutical Corporation, Shijiazhuang 050015, China
  • Received:2014-02-10 Online:2014-05-25 Published:2014-03-31

摘要: 鲁米诺是一种对于不可见血迹进行增强显示的试剂,是法医科学中最敏感的显色试剂之一,同时也可作为发光试剂应用于各种生物检测体系中。出于对安全与健康的担心,该试剂在英国和其他一些欧洲国家的使用一直受到限制。本文综述了有关鲁米诺试剂对于健康的影响的研究进展,分析显示只要采取适当的防护措施,在犯罪现场或在实验室使用鲁米诺试剂的安全风险可控。

关键词: 鲁米诺, 血, 安全风险, 毒性

Abstract: Luminol is a reagent that is used to enhance the display of non-visible blood stains and it is one of the most sensitive reagents available to forensic scientists. It is also known as light-emitting reagent used in biological detection systems. However,its use has been limited particularly within the UK and some other European countries, predominantly due to concerns about health and safety of the reagent. This paper reviews current research progress of effects of luminol on health. It showed that there is no impact on health when using luminol at the crime scene or in the laboratory if suitable protective measures are taken.

Key words: luminol, blood, safety risk, toxicity