关键词: IL-6, 新陈代谢, 癌症

Abstract: Interleukin IL-6 is widely exist in inflammatory, and it is frequently viewed as a proinflammatory cytokine. IL-6 has parallel functions with tumor necrosis factor (TNF) and IL-1β in the context of inflammation. IL-6 can stimulate activation of B cell proliferation and secrete antibody, can stimulate T cell proliferation and CTL activation, can stimulate synthesis acute phase proteins of the liver cells and participate in inflammation, can promote the blood cells development. However, accumulating evidence points to a broader role of IL-6 in a variety of (patho)physiological conditions, including functions related to the resolution of inflammation. This paper reviewed recent findings on the complex biological functions governed by IL-6 signaling, focused on its role in inflammation-associated cancer and metabolic disorders such as obesity, liver metabolism, skeletal muscle metabolism and exercise. Finally, the paper outlined important areas of inquiry towards understanding this pleiotropic cytokine, which was expected to provide reference for IL-6 application in disease treatment.

Key words: IL-6, metabolism, cancer