胰岛素生长因子2 mRNA结合蛋白3与肿瘤的相关性研究进展

doi:10.19586/j.2095-2341.2020.0162

生物技术进展 ›› 2021, Vol. 11 ›› Issue (6): 711-717.DOI: 10.19586/j.2095-2341.2020.0162

胰岛素生长因子2 mRNA结合蛋白3与肿瘤的相关性研究进展

郭子豪¹(), 裴铁民¹, 梁德森¹(), 袁帆²

^1.哈尔滨医科大学附属第一医院肛肠外科，哈尔滨 150001
^2.四川大学华西医院护理部，成都 610041

收稿日期:2020-12-18 接受日期:2021-04-14 出版日期:2021-11-25 发布日期:2021-11-26
通讯作者: 梁德森
作者简介:郭子豪 E-mail:694831261@qq.com；
基金资助:
国家自然科学基金项目(81602050)

Progress on Correlation Between Insulin Growth Factor 2 mRNA Binding Protein 3 and Tumor

Zihao GUO¹(), Tiemin PEI¹, Desen LIANG¹(), Fan YUAN²

^1.Department of Anorectal Surgery，the First Affiliated Hospital of Harbin Medical University，Harbin 150001，China
^2.West China School of Nursing，West China Hospital of Sichuan University，Chengdu 610041，China

Received:2020-12-18 Accepted:2021-04-14 Online:2021-11-25 Published:2021-11-26
Contact: Desen LIANG

摘要/Abstract

摘要：

RNA结合蛋白是生物体生命周期中重要的调节物质。作为RNA结合蛋白中的一种，胰岛素生长因子2 mRNA结合蛋白3（insulin growth factor 2 mRNA binding protein 3，IGF2BP3）介导癌症细胞的发生、发展及疾病预后和转归，因此对于IGF2BP3致癌作用的发生机制、通路传导作用机制以及基于IGF2BP3分子治疗靶点的探究具有重要意义。通过阐述IGF2BPs家族具有的生物学功能，IGF2BP3在肿瘤和疾病的相关性，以及IGF2BP3在现代临床治疗的应用前景，以期为IGF2BP3基因的进一步研究提供理论依据。

关键词: IGF2BP3, 癌症, 分子靶点

Abstract:

RNA binding protein is an important regulator in the life cycle of organisms. As one of the RNA binding proteins， insulin growth factor 2 mRNA binding protein 3 （IGF2BP3） mediates the occurrence and development of cancer cells as well as the prognosis and outcome of diseases. Therefore， it is great significance to explore the mechanism of IGF2BP3 carcinogenesis， the mechanism of pathway conduction， and the therapeutic target based on IGF2BP3 molecule. To elaborate the biological functions of the IGF2BPs family， the relevance of IGF2BP3 in some tumors and diseases， the application prospects of IGF2BP3 in modern clinical treatment， we aimed to provide a theoretical basis for further research on the IGF2BP3 gene.

Key words: IGF2BP3, cancer, molecular targets

中图分类号:

郭子豪, 裴铁民, 梁德森, 袁帆. 胰岛素生长因子2 mRNA结合蛋白3与肿瘤的相关性研究进展[J]. 生物技术进展, 2021, 11(6): 711-717.

Zihao GUO, Tiemin PEI, Desen LIANG, Fan YUAN. Progress on Correlation Between Insulin Growth Factor 2 mRNA Binding Protein 3 and Tumor[J]. Current Biotechnology, 2021, 11(6): 711-717.

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胰岛素生长因子2 mRNA结合蛋白3与肿瘤的相关性研究进展

Progress on Correlation Between Insulin Growth Factor 2 mRNA Binding Protein 3 and Tumor

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