关键词: 癌症化疗, 介孔二氧化硅, 可控药物释放, 靶向药物输送

Abstract: Cancer chemotherapy normally produces systemic toxicity and undesired side effects on patients. In order to improve the chemotherapy, its desiderated to develop new type of nanomaterials for controlled drug release and targeted drug delivery. Mesoporous silica nanoparticles (MSNs) have attracted much attention for their potential use as drug delivery carriers. The unique properties of MSNs, such as high surface area, uniform mesoporous, tunable nanoparticle size and easy chemical functionalization, make them highly suitable as a therapeutic delivery vehicle. This article reviewed recent progress on controlled drug release and targeted drug delivery of MSNs, and prospected development as drug delivery carriers for cancer therapy.

Key words: cancer chemotherapy, mesoporous silica nanoparticles, controlled drug release, targeted drug delivery