关键词: STAT3, JAK2/STAT3, 癌症, 抗癌药物靶点

Abstract: Compared with conventional chemotherapy, targeted drug therapy can better distinguish normal cells from tumor cells, and then kill tumor cells more specifically without damaging normal cells. As a signal transduction pathway stimulated by cytokines, Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway is involved in many important biological processes, such as cell proliferation, differentiation and immune regulation. JAK2/STAT3 signaling pathway is an important component of JAK/STAT signaling pathway, which has been proved to be over-activated in a variety of tumor cells, particularly in some solid tumor cells, so it is expected to become a new target of anticancer drugs. Based on this, the roles of JAK2/STAT3 signaling pathway molecules in liver cancer, breast cancer and pancreatic cancer were reviewed, and then expounded from the perspectives of JAK2/STAT3 signaling pathway molecules participating in tumor cell proliferation, inducing apoptosis and mediating invasion and metastasis, so as to provide theoretical guidance for improving the effect of cancer precision therapy and open up new approaches for cancer treatment.

Key words: STAT3, JAK2/STAT3, cancer, anticancer drug target