关键词: 硒, 空腹血糖受损, 血糖, 胰岛素

Abstract: To investigate the effects of selenium (Se) supplementation on fsting blood glucose (FBG) level, fsting insulin (FINS) level, insulin resistance and insulin sensitivity in rats with impired fsting glucose, 40 rats were randomly divided into control group, high-fat diet (HFD, 0.3 mg/kg Se) group, HFD supplemented with two levels of Se (HFD+Se+, 0.6 mg/kg Se; HFD+Se++, 1.2 mg/kg Se) groups. FBG and FINS were measured at the beginning and the fifth, tenth, sixteenth weeks of the experiment. Insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI) were calculated according FBG and FINS. As a result, the body weight of rats was significantly higher in high-fat diet groups (including Se supplementation) than control group. From the tenth week, FBG and FINS significantly increased in 3 groups with high fat diet, demonstrating impaired fasting glucose in these rats. At sixteenth weeks, FINS was significantly decreased in HFD+Se+ and HFD+Se++ groups than in HFD group. HOMA-IR was also significantly decreased in HFD+Se+ and HFD+Se++ groups than in HFD group. On the other hand, ISI was significantly increased in HFD+Se++ group than in HFD group. In conclusion, Se supplementation improves insulin resistance and increases insulin sensitivity.

Key words: selenium, impired fsting glucose, blood glucose, insulin