关键词: 功能核酸, DNA水凝胶, 理化特性, 生物传感, 靶向运输

Abstract:

Since DNA was developed as a nanoscale self-assembly material, it has connected the two major fields of life science and material science with its adjustable multifunctionality, convenient programmability, accurate molecular recognition capability, high versatility, superior biocompatibility and biodegradability. Benefiting from the structural properties of DNA nanomaterials, functional nucleic acid DNA hydrogels formed by cross-linking and self-assembly using functional nucleic acids as building blocks have become a research hotspot in the field of new materials. Based on this situation, the main physicochemical properties of functional nucleic acid DNA hydrogels were summarized. In the meanwhile, the application progress of functional nucleic acid DNA hydrogels in the fields of biomedicine, molecular detection and environmental engineering such as drug delivery and targeted therapy, biosensing, construction of three-dimensional tissues, etc. in recent years was further reviewed. Finally, the key points and directions that should be considered while designing and constructing functional nucleic acid DNA hydrogels were summarized from the perspectives of life science and material science, in order to assist the research and application of DNA hydrogels in multidisciplinary fields.

Key words: functional nucleic acids, DNA hydrogels, physicochemical properties, biosensing, targeted transport