氢生物医学效应在疏解自由基氧化应激的分子机制

doi:10.19586/j.2095-2341.2022.0116

生物技术进展 ›› 2022, Vol. 12 ›› Issue (4): 490-496.DOI: 10.19586/j.2095-2341.2022.0116

氢生物医学效应在疏解自由基氧化应激的分子机制

陶鸽如(), 秦树存()

山东第一医科大学（山东省医学科学院）泰山氢生物医学研究院，山东泰安 271000

收稿日期:2022-06-30 接受日期:2022-07-04 出版日期:2022-07-25 发布日期:2022-08-10
通讯作者: 秦树存
作者简介:陶鸽如 E-mail：grtao@sdfmu.edu.cn；
基金资助:
国家自然科学基金项目(81770855);山东第一医科大学学术提升计划项目(2019QL010)

Molecular Mechanism of Hydrogen Biomedicine in Relieving Free Radical Oxidative Stress

Geru TAO(), Shucun QIN()

Taishan Institute for Hydrogen Biomedical Research，Shandong First Medical University & Shandong Academy of Medical Sciences，Shandong Tai′an 271000，China

Received:2022-06-30 Accepted:2022-07-04 Online:2022-07-25 Published:2022-08-10
Contact: Shucun QIN

摘要/Abstract

摘要：

氢分子（H₂）作为有害自由基清除剂的选择性抗氧化新机制，为自由基生物医学理论研究和应用提供了新的方向。自2007年H₂首次被报道具有生物学效应以来，已在缺血/再灌注损伤、代谢综合征、炎症和癌症等疾病模型和人类疾病中被证实。虽然H₂的医学作用靶点仍存在争议，但大量的研究已证明H₂生物学效应具有医用气体作用和健康促进作用。系统地介绍了H₂对生物体及细胞调控的研究进展，阐述了H₂的抗氧化、抗炎和抗凋亡作用，探讨了H₂对线粒体和内质网的保护、细胞内信号通路的调节和免疫系统的平衡作用，以期为深入研究氢效应机制和规范氢供体应用范围提供理论依据。

关键词: 氢分子（H₂）, 自由基, 抗氧化, 分子机制

Abstract:

The selective antioxidant mechanism of hydrogen molecular （H₂）， as a scavenger of cytotoxic free radicals， has provided a new direction for research and application of free radical biomedical theory. Since the biological effect of H₂ was first reported in 2007， its beneficial biological effects have been demonstrated in animal models and human diseases， including ischemia/reperfusion injury， metabolic syndrome， inflammation and cancer. Although the medical target of H₂ is still controversial， many researches have demonstrated the medical and health promotion effect of H₂ biomedicine. This paper systematically introduced the research progress of H₂ regulating organisms and cellular biology deciphering its anti-oxidative， anti-inflammatory and antiapoptotic effect， and the protection of mitochondria and endoplasmic reticulum， as well as the regulation effect of intracellular signaling pathways and immune system， which amied to provide systemic knowledge for further research on the H₂ bio-mechanism and standard application.

Key words: hydrogen molecular （H₂）, free radicals, anti-oxidation, molecular mechanism

中图分类号:

陶鸽如, 秦树存. 氢生物医学效应在疏解自由基氧化应激的分子机制[J]. 生物技术进展, 2022, 12(4): 490-496.

Geru TAO, Shucun QIN. Molecular Mechanism of Hydrogen Biomedicine in Relieving Free Radical Oxidative Stress[J]. Current Biotechnology, 2022, 12(4): 490-496.

图/表 2

图1 H2应对氧化应激的主要生物学效应注：向上箭头代表上调表达，向下箭头代表抑制表达。·OH—羟基自由基；Nrf2—红系衍生核因子2相关因子2；SOD—超氧化物歧化酶；CAT—过氧化氢酶；GPX—谷胱甘肽过氧化物酶；NF-κB—核因子κB；MAPK—丝裂原活化蛋白激酶；LKB1—肝激酶B1；AMPK—腺苷酸活化蛋白激酶；FoxO1—叉头转录因子1；PI3K—磷酸肌醇3激酶；Akt—苏氨酸激酶；Foxp3—叉头蛋白3；CD—分化群；Treg—调节性T细胞；Th—辅助性T细胞；IL-10—白介素10。

Fig. 1 The main biological effects of hydrogen molecular under oxidative stress

图2 H2在氧化应激下调控信号通路的分子机制[41]注：红色虚线表示激活或抑制均可能发生。PI3k—磷酸肌醇3激酶；Akt—苏氨酸激酶；eNOS—内皮一氧化氮合酶；GSK—糖原合成酶激酶；Foxo3a—叉头转录因子3a；AMPK—腺苷酸活化蛋白激酶；Foxo1—叉头转录因子1；CAT—过氧化氢酶；·OH—羟基自由基；ONOO-—过氧亚硝酸阴离子；Nrf2—红系衍生核因子2相关因子2；SOD—超氧化物歧化酶；GPx—谷胱甘肽过氧化物酶；MAP3Ks—丝裂原活化蛋白激酶激酶；JNK—c-Jun氨基末端激酶；ERKs—细胞外信号调节激酶；NOX—NADPH氧化酶；IκB—核因子κB抑制蛋白； NF-κB—核因子κB。

Fig. 2 The molecular mechanism of hydrogen regulating signaling pathway under oxidative stress[41]

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氢生物医学效应在疏解自由基氧化应激的分子机制

Molecular Mechanism of Hydrogen Biomedicine in Relieving Free Radical Oxidative Stress

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