生物技术进展 ›› 2022, Vol. 12 ›› Issue (4): 490-496.DOI: 10.19586/j.2095-2341.2022.0116
收稿日期:
2022-06-30
接受日期:
2022-07-04
出版日期:
2022-07-25
发布日期:
2022-08-10
通讯作者:
秦树存
作者简介:
陶鸽如 E-mail:grtao@sdfmu.edu.cn;
基金资助:
Received:
2022-06-30
Accepted:
2022-07-04
Online:
2022-07-25
Published:
2022-08-10
Contact:
Shucun QIN
摘要:
氢分子(H2)作为有害自由基清除剂的选择性抗氧化新机制,为自由基生物医学理论研究和应用提供了新的方向。自2007年H2首次被报道具有生物学效应以来,已在缺血/再灌注损伤、代谢综合征、炎症和癌症等疾病模型和人类疾病中被证实。虽然H2的医学作用靶点仍存在争议,但大量的研究已证明H2生物学效应具有医用气体作用和健康促进作用。系统地介绍了H2对生物体及细胞调控的研究进展,阐述了H2的抗氧化、抗炎和抗凋亡作用,探讨了H2对线粒体和内质网的保护、细胞内信号通路的调节和免疫系统的平衡作用,以期为深入研究氢效应机制和规范氢供体应用范围提供理论依据。
中图分类号:
陶鸽如, 秦树存. 氢生物医学效应在疏解自由基氧化应激的分子机制[J]. 生物技术进展, 2022, 12(4): 490-496.
Geru TAO, Shucun QIN. Molecular Mechanism of Hydrogen Biomedicine in Relieving Free Radical Oxidative Stress[J]. Current Biotechnology, 2022, 12(4): 490-496.
图1 H2应对氧化应激的主要生物学效应注:向上箭头代表上调表达,向下箭头代表抑制表达。·OH—羟基自由基;Nrf2—红系衍生核因子2相关因子2;SOD—超氧化物歧化酶;CAT—过氧化氢酶;GPX—谷胱甘肽过氧化物酶;NF-κB—核因子κB;MAPK—丝裂原活化蛋白激酶;LKB1—肝激酶B1;AMPK—腺苷酸活化蛋白激酶;FoxO1—叉头转录因子1;PI3K—磷酸肌醇3激酶;Akt—苏氨酸激酶;Foxp3—叉头蛋白3;CD—分化群;Treg—调节性T细胞;Th—辅助性T细胞;IL-10—白介素10。
Fig. 1 The main biological effects of hydrogen molecular under oxidative stress
图2 H2在氧化应激下调控信号通路的分子机制[41]注:红色虚线表示激活或抑制均可能发生。PI3k—磷酸肌醇3激酶;Akt—苏氨酸激酶;eNOS—内皮一氧化氮合酶;GSK—糖原合成酶激酶;Foxo3a—叉头转录因子3a;AMPK—腺苷酸活化蛋白激酶;Foxo1—叉头转录因子1;CAT—过氧化氢酶;·OH—羟基自由基;ONOO-—过氧亚硝酸阴离子;Nrf2—红系衍生核因子2相关因子2;SOD—超氧化物歧化酶;GPx—谷胱甘肽过氧化物酶;MAP3Ks—丝裂原活化蛋白激酶激酶;JNK—c-Jun氨基末端激酶;ERKs—细胞外信号调节激酶;NOX—NADPH氧化酶;IκB—核因子κB抑制蛋白; NF-κB—核因子κB。
Fig. 2 The molecular mechanism of hydrogen regulating signaling pathway under oxidative stress[41]
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