关键词: 人转铁蛋白, 分离纯化, 临床应用

Abstract: Human transferrin is one of the most abundant proteins in human plasma. Its the major iron transporting protein in human plasma and extracelluar space in tissue. And it transports iron from the place of adsorption and storage to the forming red blood cells, where hemoglobin is synthesized, as well as to other requiring iron positions such as dividing cells. Transferrin is an important antioxidant and anti-microbial protein. Also, it could be applied as an additive in serum-free culture to enhance cell proliferation. Furthermore, transferrin has attracted much attention and shown comprehensive prospects in various clinical applications such as congenital atransferrinemia/hypotransferrinemia, iron binding/regulatory therapy and cancer therapy. Herein, the structure characteristics and physiological function of human transferrin were described. In addition, progress of the purification technique and clinical applications of transferrin were reviewed, which was expected to promote the clinical application of transferrin.

Key words: human transferrin, purification, clinical applications