关键词: 骨关节炎, 滑膜病变, 体液, 生物学标志物

Abstract:

Osteoarthritis （OA） is a disease characterized by progressive articular cartilage degradation， osteophyte formation， and subchondral bone sclerosis. In recent years， studies have found that the inflammation of synovium is also an important pathological mechanism in the pathogenesis of osteoarthritis. The serum and synovial fluid of patients with osteoarthritis contain a large number of metabolites of synovial cells and chondrocytes， such as collagen degradation products， C-reactive protein degradation products， hyaluronic acid， cytokines， and glycoproteins. These metabolites of synovial cells or chondrocytes are closely related to osteoarthritis， and they play important roles in the occurrence and development of synovial diseases of osteoarthritis， which can reflect the degree of inflammation of joint synovium and the progress of osteoarthritis in patients with osteoarthritis to a certain extent. The synovial lesions of early osteoarthritis are difficult to be identified and diagnosed in medical imaging examinations. Therefore， finding sensitive and specific biomarkers related to osteoarthritis synovial lesions is helpful for osteoarthritis synovium early diagnosis of inflammation and evaluation of its progress. This paper summarized the research progress of the relationship between metabolites of synovial cells or chondrocytes above and osteoarthritis synovial lesions， which was expected to provide a theoretical basis for the development of corresponding biochemical detection methods and drugs in the future.

Key words: osteoarthritis, synovial disease, body fluid, biomarkers