AMPK/SIRT1/PPARγ/PGC1α轴及其相关因子在骨关节炎脂质代谢中的作用

doi:10.19586/j.2095-2341.2021.0019

生物技术进展 ›› 2021, Vol. 11 ›› Issue (6): 718-723.DOI: 10.19586/j.2095-2341.2021.0019

AMPK/SIRT1/PPARγ/PGC1α轴及其相关因子在骨关节炎脂质代谢中的作用

梁传财(), 易鹏, 邱波()

武汉大学人民医院骨关节外科，武汉 430060

收稿日期:2021-02-04 接受日期:2021-04-14 出版日期:2021-11-25 发布日期:2021-11-26
通讯作者: 邱波
作者简介:梁传财 E-mail：729691628@qq.com 13995970295；
基金资助:
湖北省科技支撑计划项目(2015BCA316);湖北省武汉市科技计划项目(2016060101010045)

Effects of AMPK/SIRT1/PPARγ/PGC1α Axis and Related Factors on Lipid Metabolism in Osteoarthritis

Chuancai LIANG(), Peng YI, Bo QIU()

Department of Orthopedics，Renmin Hospital of Wuhan University，Wuhan 430060，China

Received:2021-02-04 Accepted:2021-04-14 Online:2021-11-25 Published:2021-11-26
Contact: Bo QIU

摘要/Abstract

摘要：

骨关节炎（osteoarthritis，OA）是一种退行性关节疾病，以软骨变性、骨硬化和慢性滑膜炎症为主要临床特征。在骨关节炎病理改变中，脂质代谢异常与软骨、骨的退行性改变密切相关。AMP活化的蛋白激酶（adenosine monophosphate?activated protein kinase，AMPK）活化后，可通过调节脂肪酸合成的关键酶，如肉碱脂酰转移酶（carnitine palmitoyltransferase 1，CPT?1）、链酰基辅酶A脱氢酶（medium chain acyl?CoA dehydrogenase，MCAD）和软骨细胞自噬功能，进而调节软骨细胞脂质代谢，以延缓OA的发展。过氧化物酶体增殖物激活受体γ（peroxisomal proliferator?activated receptor γ，PPARγ）和过氧化物酶体增殖物激活受体γ共激活因子1α（peroxisomal proliferator?activated receptor γ coactivator 1α，PGC?1α）也具有相似的生理功能。AMPK与沉默信息调节因子1（silencing information regulator 1，SIRT1）的激活及相互作用能介导PPARγ、PGC?1α的信号转导及生理功能。综述了AMPK/SIRT1/PPARγ/PGC1α轴在OA发病机制中的作用的最新进展，以期为OA的治疗及预防研究提供参考。

关键词: 骨关节炎, 脂代谢, 蛋白激酶, 过氧化物酶体增殖物激活受体γ, 过氧化物酶体增殖物激活受体γ共激活因子1α

Abstract:

Osteoarthritis （OA） is a degenerative joint disease with cartilage degeneration， osteosclerosis， and chronic synovial inflammation as the main clinical features. In the pathological changes of osteoarthritis， abnormal lipid metabolism is closely related to the degenerative changes of cartilage and bone. After the activation of adenosine monophosphate?activated protein kinase （AMPK）， which can regulate the lipid metabolism of chondrocytes by regulating the key enzymes of fatty acid synthesis carnitine palmitoyltransferase 1（CPT?1）， medium chain acyl?CoA dehydrogenase （MCAD） and chondrocyte autophagy to delay the development of OA. Peroxisomal proliferator?activated receptor γ （PPARγ） and peroxisomal proliferator?activated receptor γ coactivator 1α （PGC?1α） also have similar physiological functions.The activation and interaction of AMPK and silencing information regulator 1 （SIRT1） can mediate the signal transduction and physiological functions of PPARγ and PGC?1α. This paper summarized the role of AMPK/SIRT1/PPARγ/PGC1α axis in the pathogenesis of OA， which was expected to provide reference for therapy and prevention research of OA.

Key words: osteoarthritis, lipid metabolism, protein kinase, peroxisome proliferator?activated receptor γ, peroxisome proliferator?activated receptor γ?coactivator 1α

中图分类号:

R684

梁传财, 易鹏, 邱波. AMPK/SIRT1/PPARγ/PGC1α轴及其相关因子在骨关节炎脂质代谢中的作用[J]. 生物技术进展, 2021, 11(6): 718-723.

Chuancai LIANG, Peng YI, Bo QIU. Effects of AMPK/SIRT1/PPARγ/PGC1α Axis and Related Factors on Lipid Metabolism in Osteoarthritis[J]. Current Biotechnology, 2021, 11(6): 718-723.

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AMPK/SIRT1/PPARγ/PGC1α轴及其相关因子在骨关节炎脂质代谢中的作用

Effects of AMPK/SIRT1/PPARγ/PGC1α Axis and Related Factors on Lipid Metabolism in Osteoarthritis

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