核酸自组装纳米递送载体的研究进展

doi:10.19586/j.2095-2341.2021.0160

生物技术进展 ›› 2022, Vol. 12 ›› Issue (3): 352-357.DOI: 10.19586/j.2095-2341.2021.0160

核酸自组装纳米递送载体的研究进展

陈可仁¹^,²(), 汪未申¹, 朱龙佼¹, 张洋子¹^,², 贺晓云², 黄昆仑², 许文涛¹()

^1.中国农业大学营养与健康系，食品精准营养与质量控制教育部重点实验室，北京 100083
^2.中国农业大学食品科学与营养工程学院，北京 100083

收稿日期:2021-09-26 接受日期:2021-11-02 出版日期:2022-05-25 发布日期:2022-05-26
通讯作者: 许文涛
作者简介:陈可仁 E-mail：yvonnechenkr@cau.edu.cn；
基金资助:
河北省重点研发计划项目(21372801D);北京市农业科技项目(PXM2021_014207_000037)

Research Progress of Nucleic Acid⁃based Self⁃assembling Nanocarriers

Keren CHEN¹^,²(), Weishen WANG¹, Longjiao ZHU¹, Yangzi ZHANG¹^,², Xiaoyun HE², Kunlun HUANG², Wentao XU¹()

^1.Key Laboratory of Precision Nutrition and Food Quality，Department of Nutrition and Health，China Agricultural University，Beijing 100083，China
^2.College of Food Science and Nutritional Engineering，China Agricultural University，Beijing 100083，China

Received:2021-09-26 Accepted:2021-11-02 Online:2022-05-25 Published:2022-05-26
Contact: Wentao XU

摘要/Abstract

摘要：

随着核酸纳米技术的飞速发展，核酸自组装纳米载体已成为药物递送领域的研究热点。针对核酸自组装纳米载体在药物递送中的应用进展进行了系统综述，讨论了不同的核酸自组装策略，阐述了多种靶向递送和药物控制释放方法，同时，总结了核酸自组装纳米递送载体在蛋白质药物、核酸药物、小分子药物和纳米药物递送中的应用，并针对该领域的挑战和未来发展趋势进行了总结和展望，以期为药物递送领域和新型药物系统研究提供参考。

关键词: 核酸自组装纳米递送载体, 药物递送, 核酸药物, 纳米药物

Abstract:

As the rapid development of nucleic acid nanotechnology， nucleic acid-based self-assembling nanocarriers have become a research focus in the field of drug delivery. This article reviewed the application of nucleic acid-based self-assembling nanocarriers in drug delivery， discussed different nucleic acid-based self-assembling strategies， and expounded a variety of targeted delivery and controlled drug release methods. In addition， this article also summarized the application of nucleic acid-based self-assembling nanocarrier in the delivery of protein drugs， nucleic acid drug， small molecule drugs and nanodrugs. At the same time， the challenges and future development trends in this field were summarized and prospected， in order to provide references for the development of drug delivery fields and new drug systems.

Key words: nucleic acid-based self-assembling nanocarriers, drug delivery, nucleic acid drugs, nanodrugs

中图分类号:

陈可仁, 汪未申, 朱龙佼, 张洋子, 贺晓云, 黄昆仑, 许文涛. 核酸自组装纳米递送载体的研究进展[J]. 生物技术进展, 2022, 12(3): 352-357.

Keren CHEN, Weishen WANG, Longjiao ZHU, Yangzi ZHANG, Xiaoyun HE, Kunlun HUANG, Wentao XU. Research Progress of Nucleic Acid⁃based Self⁃assembling Nanocarriers[J]. Current Biotechnology, 2022, 12(3): 352-357.

图/表 1

参考文献 35

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核酸自组装纳米递送载体的研究进展

Research Progress of Nucleic Acid⁃based Self⁃assembling Nanocarriers

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