生物技术进展 ›› 2012, Vol. 2 ›› Issue (2): 98-103.DOI: 10.3969/j.issn.2095-2341.2012.02.

• 进展评述 • 上一篇    下一篇

假单胞菌中CbrA-CbrB二元调控系统的研究进展

代淑贤,韩云蕾,燕永亮,林敏,平淑珍*   

  1. 中国农业科学院生物技术研究所, 北京 100081
  • 收稿日期:2011-12-14 出版日期:2012-03-25 发布日期:2011-01-09
  • 通讯作者: 通讯作者:平淑珍,研究员,硕士生导师,主要从事微生物固氮研究。E-mail:pingszhen@yahoo.com.cn
  • 作者简介:代淑贤,硕士研究生,研究方向为固氮微生物与基因工程。E-mail:dsx0501@163.com。
  • 基金资助:

    国家自然科学基金项目(30970093,31070084)资助。

Research Progress on CbrA-CbrB Two-component System in Pseudomonas

DAI Shu-xian, HAN Yun-lei, YAN Yong-liang, LIN Min, PING Shu-zhen   

  1. Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  • Received:2011-12-14 Online:2012-03-25 Published:2011-01-09

摘要: CbrA-CbrB(catabolic regulation)是一种介导信号传递的二元调控系统,CbrA-CbrB与其他调控系统形成相互依赖、逐级调节的严格的调控网络,尤其是与NtrB-NtrC(nitrogen assimilation)偶联,精确地调节自身的代谢、生理和行为来适应复杂的外界环境,在微生物适应环境的过程中起着重要的调控作用。本文对假单胞菌中CbrA-CbrB的结构、功能和可能的作用机制作了简单的综述。

关键词: 假单胞菌, CbrA-CbrB, 碳氮代谢

Abstract: A two-component system,CbrA-CbrB(catabolic regulation),was discovered as an signal-transduction system. CbrA-CbrB forms networks with other regulation systems that involve more than one system, especially couples with the NtrB-NtrC(nitrogen assimilation), and shows dependencies and hierarchies,which makes it easily adapt very complex processes and plays an important role in the process of microbial adaptation to the environment. In this article,we have tried to bring together information to give a broad perspective of CbrA-CbrB proteins’structure and function and the possible mechanism in Pseudomonas.

Key words: Pseudomonas, CbrA-CbrB, nitrogen and carbon metabolism