关键词: 群体感应系统, 群体感应抑制剂, 植物精油, 铜绿假单胞菌

Abstract: Quorum sensing (QS) is a kind of communication mechanism between individual bacteria, which widely exists in bacteria. Pseudomonas aeruginosa is an opportunistic pathogen of human beings, which has at least three QS systems, namely las, rhl and pqs systems, and there is a cascade regulation relationship among them, which jointly regulate the expression of many virulence genes and the production of virulence factors. In recent years, it has become a new strategy to control the virulence and pathogenicity of P. aeruginosa for the treatment of this pathogen infection by inhibiting its QS systems. Plant essential oil is a natural quorum sensing inhibitors (QSI). Many active compounds of essential oil can inhibit the QS system of P. aeruginosa, and no drug resistance has been found in bacteria. Based on this, the composition and cascade regulation of QS system of P. aeruginosa were carded, the QS inhibition mechanism and inhibitory activity of plant essential oils were briefly introduced, and the research progress in the inhibitory effects of terpenoids, aromatic compounds, aliphatic compounds and sulfur-containing and nitrogen-containing compounds on QS system of P. aeruginosa was emphatically reviewed, in order to provide reference for the related research of finding and screening safe and efficient bacterial QSI from natural compounds, and lay a theoretical foundation for the prevention and control of pathogenic bacteria.

Key words: quorum sensing systems, quorum sensing inhibitors, essential oils, Pseudomonas aeruginosa