SP140蛋白对几种肿瘤或感染相关基因表达调控和一些免疫性疾病的影响

doi:10.19586/j.2095-2341.2024.0170

生物技术进展 ›› 2025, Vol. 15 ›› Issue (4): 668-674.DOI: 10.19586/j.2095-2341.2024.0170

• 进展评述 • 上一篇

SP140蛋白对几种肿瘤或感染相关基因表达调控和一些免疫性疾病的影响

董子涵(), 邵金辉()

湖北文理学院基础医学院，湖北襄阳　441053

收稿日期:2024-11-03 接受日期:2025-03-05 出版日期:2025-07-25 发布日期:2025-09-08
通讯作者: 邵金辉
作者简介:董子涵 E-mail:2714928569@qq.com；
基金资助:
湖北文理学院博士科研启动基金项目(2020170393)

The Effect of SP140 Protein on the Expression Regulation of Several Tumor or Infection Related Genes and Some Immune Diseases

Zihan DONG(), Jinhui SHAO()

College of Basic Medicine，Hubei University of Arts and Science，Hubei Xiangyang 441053，China

Received:2024-11-03 Accepted:2025-03-05 Online:2025-07-25 Published:2025-09-08
Contact: Jinhui SHAO

摘要/Abstract

摘要：

人SP140是一种白细胞特异性核蛋白，其抑制剂为GSK761。它属于斑点蛋白（speck-like protein，SP）家族，优先在免疫细胞中表达。目前研究发现，SP140可以激活基因转录，参与基因调控，并且在免疫调节中发挥着重要作用。系统综述了SP140的基本分子生物学特征、SP140在基因表达调控方面的作用、SP140与免疫反应的关系。总结了SP140与免疫性疾病的关系，包括原发性胆汁性肝硬化、多发性硬化症、克罗恩病、慢性淋巴细胞白血病、艾滋病等，以期增进对这些疾病发病机理的理解，并有望助力其诊断或治疗的改进。

关键词: SP140, 基因表达, 标志物, 免疫反应, 疾病

Abstract:

Human SP140， a leukocyte-specific nuclear protein inhibited by GSK761， belongs to the speck-like protein （SP） family and is predominantly expressed in immune cells. Current research indicates that SP140 activates gene transcription， regulates gene expression， and plays a significant role in immune modulation. This review systematically summarized the fundamental molecular characteristics of SP140， its role in the regulation of gene expression， and its involvement in immune responses. Furthermore， it detailed the association of SP140 with numerous diseases， primarily immune-related disorders， including primary biliary cholangitis （formerly cirrhosis）， multiple sclerosis， Crohn's disease， chronic lymphocytic leukemia， acquired immune deficiency syndrome（AIDS）， in order to enhance the understanding of the pathogenesis of these diseases and potentially contributing to improvements in their diagnosis and treatment.

Key words: SP140, gene expression, markers, immune response, disease

中图分类号:

R392.32

董子涵, 邵金辉. SP140蛋白对几种肿瘤或感染相关基因表达调控和一些免疫性疾病的影响[J]. 生物技术进展, 2025, 15(4): 668-674.

Zihan DONG, Jinhui SHAO. The Effect of SP140 Protein on the Expression Regulation of Several Tumor or Infection Related Genes and Some Immune Diseases[J]. Current Biotechnology, 2025, 15(4): 668-674.

图/表 1

参考文献 41

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疾病类型	与SP140有关的疾病
自身免疫性疾病	原发性胆汁性肝硬化、克罗恩病、多发性硬化症、炎症性肠病、川崎病、慢性淋巴细胞白血病、艾滋病
恶性肿瘤	淋巴瘤C3、喉鳞状细胞癌、宫颈鳞状细胞癌
感染性疾病	嗜肺军团菌感染、结核分枝杆菌感染
神经系统及眼部疾病	视网膜神经退行性疾病
睡眠相关疾病	过度日间嗜睡、睡眠呼吸障碍、阻塞性睡眠呼吸暂停

疾病类型	与SP140有关的疾病
自身免疫性疾病	原发性胆汁性肝硬化、克罗恩病、多发性硬化症、炎症性肠病、川崎病、慢性淋巴细胞白血病、艾滋病
恶性肿瘤	淋巴瘤C3、喉鳞状细胞癌、宫颈鳞状细胞癌
感染性疾病	嗜肺军团菌感染、结核分枝杆菌感染
神经系统及眼部疾病	视网膜神经退行性疾病
睡眠相关疾病	过度日间嗜睡、睡眠呼吸障碍、阻塞性睡眠呼吸暂停

SP140蛋白对几种肿瘤或感染相关基因表达调控和一些免疫性疾病的影响

The Effect of SP140 Protein on the Expression Regulation of Several Tumor or Infection Related Genes and Some Immune Diseases

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