PFASs对子代神经发育毒性的研究进展

doi:10.19586/j.2095-2341.2025.0023

生物技术进展 ›› 2025, Vol. 15 ›› Issue (4): 661-667.DOI: 10.19586/j.2095-2341.2025.0023

• 进展评述 • 上一篇

PFASs对子代神经发育毒性的研究进展

熊利欣¹(), 王俞杰¹(), 李忠乐¹(), 钟恩鸣¹, 于寿洋¹, 姜雨欣¹, 隋宏书¹(), 林荣花²()

^1.山东第一医科大学临床与基础医学院，济南 250000
^2.解放军第九六〇医院肾内科，济南 250000

收稿日期:2025-02-24 接受日期:2025-03-28 出版日期:2025-07-25 发布日期:2025-09-08
通讯作者: 隋宏书,林荣花
作者简介:熊利欣 E-mail: 2948935041@qq.com；
王俞杰 E-mail: 2579728429@qq.com
李忠乐 E-mail: 2813782795@qq.com。第一联系人：（熊利欣、王俞杰、李忠乐并列第一作者）
基金资助:
国家自然科学基金项目(81670004);山东第一医科大学教育教学改革项目(XM2022046);山东省研究生优质课程建设项目(SDYKC21148)

Research Progress on Neurodevelopmental Toxicity in Offspring of PFASs Exposure

Lixin XIONG¹(), Yujie WANG¹(), Zhongle LI¹(), Enming ZHONG¹, Shouyang YU¹, Yuxin JIANG¹, Hongshu SUI¹(), Ronghua LIN²()

^1.College of Clinical and Basic Medicine，Shandong First Medical University，Jinan 250000，China
^2.Department of Nephrology，the 960th Hospital of the Chinese People's Liberation Army，Jinan 250000，China

Received:2025-02-24 Accepted:2025-03-28 Online:2025-07-25 Published:2025-09-08
Contact: Hongshu SUI,Ronghua LIN

摘要/Abstract

摘要：

全氟和多氟化合物(per and polyfluoroalkyl substances，PFASs)是一类高持久性环境污染物，其通过胎盘介导的子代神经发育毒性已成为近年研究热点。系统阐述了PFASs通过干扰甲状腺激素平衡、神经营养因子表达、神经细胞功能及表观遗传调控等多途径影响子代神经发育的分子机制，评估了现有干预策略的局限性，以期为揭示PFASs跨代毒性机制提供理论框架，并对制定母婴暴露防控政策提供参考。

关键词: PFASs, 神经毒性, 胎盘

Abstract:

Per and polyfluoroalkyl substances （PFASs）， a class of highly persistent environmental pollutants， have become a research hotspot in recent years due to their neurodevelopmental toxicity in offspring mediated by the placenta. This review systematically elaborated on the molecular mechanisms by which PFASs affect the neurodevelopment of offspring through multiple pathways， including interfering with thyroid hormone balance， the expression of neurotrophic factors， the function of neural cells， and epigenetic regulation. It also assessed the limitations of existing intervention strategie， aiming to provide a theoretical framework for revealing the transgenerational toxicity mechanism of PFASs and reference for formulating policies to prevent and control maternal and infant exposure.

Key words: PFASs, neurotoxicity, placenta

中图分类号:

Q189

熊利欣, 王俞杰, 李忠乐, 钟恩鸣, 于寿洋, 姜雨欣, 隋宏书, 林荣花. PFASs对子代神经发育毒性的研究进展[J]. 生物技术进展, 2025, 15(4): 661-667.

Lixin XIONG, Yujie WANG, Zhongle LI, Enming ZHONG, Shouyang YU, Yuxin JIANG, Hongshu SUI, Ronghua LIN. Research Progress on Neurodevelopmental Toxicity in Offspring of PFASs Exposure[J]. Current Biotechnology, 2025, 15(4): 661-667.

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PFASs对子代神经发育毒性的研究进展

Research Progress on Neurodevelopmental Toxicity in Offspring of PFASs Exposure

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