海洋真菌来源的聚酮类化合物研究进展

doi:10.19586/j.2095-2341.2024.0094

生物技术进展 ›› 2024, Vol. 14 ›› Issue (6): 993-1003.DOI: 10.19586/j.2095-2341.2024.0094

海洋真菌来源的聚酮类化合物研究进展

潘少婷(), 王博轩, 陈佳鑫, 蔡佳君, 林彦伸, 唐灵芝, 洪璇()

厦门医学院，厦门市海洋药用天然产物资源重点实验室，福建厦门 361023

收稿日期:2024-05-06 接受日期:2024-08-13 出版日期:2024-11-25 发布日期:2024-12-27
通讯作者: 洪璇
作者简介:潘少婷 E-mail：1075047301@qq.com；
基金资助:
国家级大学生创新创业训练项目(202312631001);厦门市自然科学基金面上项目(3502Z20227227);福建省自然科学基金面上项目(2022J011401);福建省教育科学“十四五”规划课题(FJJKBK22-049)

Research Progress on Polyketides from Marine Fungi

Shaoting PAN(), Boxuan WANG, Jiaxin CHEN, Jiajun CAI, Yanshen LIN, Lingzhi TANG, Xuan HONG()

Xiamen Key Laboratory of Marine Medicinal Natural Products Resources，Xiamen Medical College，Fujian Xiamen 361023，China

Received:2024-05-06 Accepted:2024-08-13 Online:2024-11-25 Published:2024-12-27
Contact: Xuan HONG

摘要/Abstract

摘要：

聚酮类化合物作为一类重要的次级代谢产物，在海洋生物中广泛分布，展现出包括抗肿瘤、抗菌、抗病毒、抗氧化及抑制酶活性在内的多种生物活性。近年来，随着对海洋资源探索的深入，源自海洋真菌的新型聚酮类化合物不断涌现，成为新药研发的重要宝库。从研究概况、生物合成途径、发酵与分离以及生物活性评估五个方面综述了海洋真菌来源的聚酮类化合物的研究进展，以期为海洋聚酮类化合物的开发与应用研究提供参考。

关键词: 海洋真菌, 聚酮类化合物, 生物合成途径, 生物活性

Abstract:

As an important class of secondary metabolites， polyketides are widely found in marine organisms and rich in biological activities such as antitumor， antibacterial， antiviral， antioxidant， and enzyme inhibition. In recent years， with the exploitation of marine resources， many novel polyketides of marine fungal origin have been discovered， which are considered to be an important source of new drugs. In this paper， the research progress of marine fungal-derived polyketides was reviewed from five aspects： research overview， biosynthetic pathway， fermentation and isolation， and biological activity， which was expected to provide reference for the study of development and application on polyketides from marine fungi.

Key words: marine fungi, polyketides, biosynthetic pathway, biological activity

中图分类号:

Q939.5

潘少婷, 王博轩, 陈佳鑫, 蔡佳君, 林彦伸, 唐灵芝, 洪璇. 海洋真菌来源的聚酮类化合物研究进展[J]. 生物技术进展, 2024, 14(6): 993-1003.

Shaoting PAN, Boxuan WANG, Jiaxin CHEN, Jiajun CAI, Yanshen LIN, Lingzhi TANG, Xuan HONG. Research Progress on Polyketides from Marine Fungi[J]. Current Biotechnology, 2024, 14(6): 993-1003.

图/表 8

图1 NR-PKSs的聚酮化合物的生物合成途径

Fig. 1 The biosynthetic pathway of polyketide compounds in NR-PKSs

图2 Aspergillus nidulans生物合成的Asperthecin产物结构

Fig. 2 Asperthecin product structure of Aspergillus nidulans biosynthesis

图3 Asperfuranone的生物合成途径注：(a)—Intermediate A； (b)—(5S)-4,5-dihydroxy-2-((3E,5E,7S)-1-hydroxy-5,7-dimethyl-2-oxonona-3,5-dien-1-yl)-5-methyl-6-oxocyclohex-1-ene-1-carbaldehyde； (c)—(5S)-1-((R,2E,4E)-4,6-dimethylocta-2,4-dienoyl)-5,6-dihydroxy-5-methyl-6,7-dihydroisobenzofuran-4(5H)-one； (d)—Asperfuranone。

Fig. 3 The biosynthetic pathway of Asperfuranone

图4 P-kotanin的生物合成途径注：(e)—4,7-dihydroxy-5-methyl-2H-chromen-2-one；(f)—7-demethylsiderin。

Fig. 4 The biosynthetic pathway of P-kotanin

表1 海洋真菌聚酮类化合物的生物合成途径进展

Table 1 Progress on the biosynthetic pathways of marine fungal polyketides

来源	生物合成关键酶	生物活性	文献
Aspergillus nidulans	AptA、结合Mn²⁺的AptB以及黄素单加氧酶AptC	生姜青枯病(姜瘟病)的防治	[17]
Asperfuranone	HR-PKSs(AteafoE)、NR-PKSs(AteafoD)以及脂肪酶	抗菌、抗氧化	[18]
Aspergillus niger	HR-PKSs、O-甲基转移酶（KtnB）	-	[21-23]
Aspergillus fumigatus	PKS-NRPSs、甲基转移酶	-	[26-28]
A．niger	AdaA、甲基转移酶（AdaD）	受体拮抗剂	[17]
Cladosporium fulvum	细胞色素P450酶、还原酶ClaC、脱水酶ClaB、脱羧酶ClaH	细胞毒性	[30]
F．fujikuroi	O-甲基转移酶Fsr2	-	[31]
A. nidulans	SlACAS	抗氧化剂	[32]

图5 Pseurotin A、Azaspirene的生物合成途径注：(g)—(6E,8E)-4-methyl-3,5-dioxo-N-((S)-1-oxo-3-phenylpropan-2-yl)undeca-6,8-dienamide；(h)—(4E,6E)-1-((S)-5-benzyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-2-methylnona-4,6-diene-1,3-dione;(i) —(5S,8S,9S)-8-benzyl-2-((1E,3E)-hexa-1,3-dien-1-yl)-9-hydroxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione；(j) —(5S,8R,9R)-8-benzyl-2-((1E,3E)-hexa-1,3-dien-1-yl)-8,9-dihydroxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione。

Fig. 5 The biosynthetic pathway of Pseurotin A、Azaspirene

图6 海洋真菌来源聚酮类化合物1~8结构式注：1—Monarubins B；2a—4-epi-onchidiol； 2b—16-epi-onchidiol； 3a—庞苷衍生物； 3b—庞苷衍生物；4—akazamicin 芳香族聚酮；5a—Verrucosidin； 5b—Deoxyverrucosidin；6a—Fusarisolin I；6b—Fusarisolin J； 6c—5-deoxybostry coidin； 7—双环聚酮； 8a~c—二苯醚类化合物； 8d—环戊烯酮类化合物。

Fig. 6 Structural formulas of polyketides 1~8 from marine fungi

图7 海洋真菌来源聚酮类化合物9~16结构式注：9—Trihydropropye A； 10—Stachybogrisephenone B； 11—Peniterphenyl A； 12a—Peniterphenyl A； 12b—Aurasperone A； 13—Chrysopyrones A 和B； 14—Oxisterigmatocystin D； 15a~e—Raistrickiones A~E；16a—2,2′,3,5′-tetrahydroxy-3′-methylbenzophenone； 16b—2,2′,5′-trihydroxy-3-methoxy-3′-methylbenzophenone；16c—1,4,7-trihydroxy-6-methylxanthone。

Fig. 7 Structural formulas of polyketides 9~16 from marine fungi

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海洋真菌来源的聚酮类化合物研究进展

Research Progress on Polyketides from Marine Fungi

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