秀丽隐杆线虫模型在记忆和遗忘行为研究中的运用

doi:10.19586/j.2095-2341.2023.0077

生物技术进展 ›› 2023, Vol. 13 ›› Issue (6): 837-843.DOI: 10.19586/j.2095-2341.2023.0077

• 进展评述 • 上一篇

秀丽隐杆线虫模型在记忆和遗忘行为研究中的运用

赵歆¹^,²(), 李鑫玉¹(), 李明浩¹, 周诗艺¹, 邓雅琪¹, 郑至远¹, 邹伟¹()

^1.昆明医科大学公共卫生学院，昆明 650500
^2.西安市公共卫生中心，西安 710299

收稿日期:2023-06-06 接受日期:2023-08-28 出版日期:2023-11-25 发布日期:2023-12-12
通讯作者: 邹伟
作者简介:赵歆E-mail: 798766529@qq.com
李鑫玉E-mail: xinyuliyx@163.com。第一联系人：（李鑫玉、赵歆并列第一作者）
基金资助:
云南省基础研究计划(昆医联合专项)(202301AY070001-194)

Application of Caenorhabditis elegans Model in the Study of Memory and Forgetting Behavior

Xin ZHAO¹^,²(), Xinyu LI¹(), Minghao LI¹, Shiyi ZHOU¹, Yaqi DENG¹, Zhiyuan ZHENG¹, Wei ZOU¹()

^1.School of Public Health，Kunming Medical University，Kunming 650500，China
^2.Xi'an Public Health Center，Xi'an 710299，China

Received:2023-06-06 Accepted:2023-08-28 Online:2023-11-25 Published:2023-12-12
Contact: Wei ZOU

摘要/Abstract

摘要：

记忆是学习和掌握新知识的基础，遗忘则有助于保持大脑记忆系统的高效性，因此记忆与遗忘是大脑神经网络正常运作的重要组成部分。秀丽隐杆线虫生物体积小、生命周期短、易于识别单个神经元，已成为神经科学和行为学领域研究的理想模型之一，基于秀丽隐杆线虫模型的研究结合高等模式生物探索记忆和遗忘的机制将有助于揭示记忆和遗忘异常相关疾病的发生。综述了秀丽隐杆线虫广泛用于挥发性物质与病原菌的记忆与遗忘行为的分子机制研究，以及转基因线虫在记忆与遗忘相关疾病中的应用，旨在为后续记忆和遗忘的研究提供理论参考。

关键词: 秀丽隐杆线虫, 记忆, 遗忘行为, 分子机制

Abstract:

Memory is the basis of learning and mastering new knowledge， and forgetting helps to maintain the efficiency of the brain memory system， so memory and forgetting are important components of the normal operation of the brain neural network. With its small size， short life cycle， and easy recognition of single neurons， Caenorhabditis elegans has become one of the ideal models for neuroscience and behavioral research. Studies based on C. elegans model combined with higher model organisms to explore the mechanisms of memory and forgetting will help reveal the occurrence of diseases related to abnormal memory and forgetting. In this paper， we reviewed the molecular mechanism of memory and forgetting behavior of C. elegans widely used in volatile substances and pathogenic bacteria， and the application of transgenic C. elegans in memory and forgetting related diseases， so as to provide theoretical reference for subsequent research on memory and forgetting.

Key words: Caenorhabditis elegans, memory, forgetting behavior, molecular mechanism

中图分类号:

赵歆, 李鑫玉, 李明浩, 周诗艺, 邓雅琪, 郑至远, 邹伟. 秀丽隐杆线虫模型在记忆和遗忘行为研究中的运用[J]. 生物技术进展, 2023, 13(6): 837-843.

Xin ZHAO, Xinyu LI, Minghao LI, Shiyi ZHOU, Yaqi DENG, Zhiyuan ZHENG, Wei ZOU. Application of Caenorhabditis elegans Model in the Study of Memory and Forgetting Behavior[J]. Current Biotechnology, 2023, 13(6): 837-843.

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秀丽隐杆线虫模型在记忆和遗忘行为研究中的运用

Application of Caenorhabditis elegans Model in the Study of Memory and Forgetting Behavior

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