大豆蛋白源性肽调节糖脂代谢机制研究进展

doi:10.19586/j.2095-2341.2021.0161

生物技术进展 ›› 2022, Vol. 12 ›› Issue (6): 853-860.DOI: 10.19586/j.2095-2341.2021.0161

大豆蛋白源性肽调节糖脂代谢机制研究进展

李岩异(), 吕娜, 陈金利, 李晓, 张卫婷, 张红霞()

华北制药金坦生物技术股份有限公司，石家庄 050035

收稿日期:2021-09-26 接受日期:2022-06-22 出版日期:2022-11-25 发布日期:2022-11-30
通讯作者: 张红霞
作者简介:李岩异 E-mail:1416305041@qq.com；

Progress on the Mechanism of Soybean Protein Derived Peptides Regulating Glucose and Lipid Metabolism

Yanyi LI(), Na LYU, Jinli CHEN, Xiao LI, Weiting ZHANG, Hongxia ZHANG()

North China Pharmaceutical Jintan Biotechnology Co. ，Ltd. ，Shijiazhuang 050035，China

Received:2021-09-26 Accepted:2022-06-22 Online:2022-11-25 Published:2022-11-30
Contact: Hongxia ZHANG

摘要/Abstract

摘要：

大豆蛋白源性肽是大豆蛋白质经酸法或酶法水解后分离精制而得到的多肽混合物，是植物蛋白源性肽的重要来源，大豆蛋白源性肽通过抑制肠道胆固醇吸收、与胆固醇的相互作用、调节胆固醇代谢相关基因（用于降低胆固醇）、甘油三酯代谢相关基因、二肽基肽酶Ⅳ和葡萄糖代谢相关基因，在降低胆固醇、降低甘油三酯、抗肥胖、抑制脂肪酸合成酶和抗糖尿病等代谢调节方面具有重要作用。综述了大豆蛋白源性肽在体内外改善脂质和糖代谢方面的生理功能，并对大豆蛋白源性肽的前景进行了展望，以期为大豆蛋白源性肽的研究与应用提供参考。

关键词: 大豆蛋白源性肽, 胆固醇, 甘油三酯, 动脉粥样硬化, 糖尿病

Abstract:

Soybean protein derived peptides is a peptide mixture obtained by separating and refining soybean protein through acid or enzymatic hydrolysis. It is an important source of plant protein derived peptides. Soybean protein derived peptides can inhibit intestinal cholesterol absorption， interact with cholesterol， regulate cholesterol metabolism related genes （used to reduce cholesterol）， triglyceride metabolism related genes， dipeptidyl peptidase Ⅳ and glucose metabolism related genes， it plays an important role in reducing cholesterol， triglycerides， anti-obesity， inhibiting fatty acid synthase and anti-diabetes and other metabolic regulation. This paper reviewed the physiological functions of soybean protein derived peptides in improving lipid and sugar metabolism in vitro and in vivo， and forecasted the prospects of soybean derived peptides， which was expected to provide reference for the research and application of soybean proteinderived peptides.

Key words: soybean protein derived peptides, cholesterol, triglycerides, atherosclerosis, diabetes

中图分类号:

李岩异, 吕娜, 陈金利, 李晓, 张卫婷, 张红霞. 大豆蛋白源性肽调节糖脂代谢机制研究进展[J]. 生物技术进展, 2022, 12(6): 853-860.

Yanyi LI, Na LYU, Jinli CHEN, Xiao LI, Weiting ZHANG, Hongxia ZHANG. Progress on the Mechanism of Soybean Protein Derived Peptides Regulating Glucose and Lipid Metabolism[J]. Current Biotechnology, 2022, 12(6): 853-860.

图/表 2

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肽源	肽序列	生物学活性
豇豆	GCTLN，QDF	低胆固醇血症
海泽尔纳特	RLLPH	抗肥胖
羽扇豆	LTFPGSAED	抗糖尿病
菜豆	INEGSLLLPH FVVAEQAGNEGFE	抗糖尿病
大豆	IAVPGEVA，LPYP	低胆固醇血症
	IAVPTGVA	低胆固醇血症,抗糖尿病
	AKSPLF，ATNPLF，FEELN，LSVSVL	抗糖尿病
	KA，VK，SY	低甘油三酯血症
	KNPQLR，EITPEKNPQLR，RKQEEDEEQQRE	低甘油三酯血症
螺旋藻	NALKCHSCHCPA LNNPSVCDCMMKAAR， NPVWKRK，CANPHELPNK	低甘油三酯血症
螺旋藻	RSELAAWSR	抗糖尿病
核桃	LPLLR	抗糖尿病

肽源	肽序列	生物学活性
豇豆	GCTLN，QDF	低胆固醇血症
海泽尔纳特	RLLPH	抗肥胖
羽扇豆	LTFPGSAED	抗糖尿病
菜豆	INEGSLLLPH FVVAEQAGNEGFE	抗糖尿病
大豆	IAVPGEVA，LPYP	低胆固醇血症
	IAVPTGVA	低胆固醇血症,抗糖尿病
	AKSPLF，ATNPLF，FEELN，LSVSVL	抗糖尿病
	KA，VK，SY	低甘油三酯血症
	KNPQLR，EITPEKNPQLR，RKQEEDEEQQRE	低甘油三酯血症
螺旋藻	NALKCHSCHCPA LNNPSVCDCMMKAAR， NPVWKRK，CANPHELPNK	低甘油三酯血症
螺旋藻	RSELAAWSR	抗糖尿病
核桃	LPLLR	抗糖尿病

肽源	肽序列	生物学活性
大豆	VAWWMY（大豆抑素）	低胆固醇血症
大豆	VHVV	低胆固醇低甘油三酯血症
大豆	LUNASIN	低胆固醇血症
大豆	YPFVV（大豆蛋白⁃5）	低甘油三酯抗糖尿病
大豆	苷元	抗糖尿病
水稻	GEQQPGM	低胆固醇血症
鹰嘴豆	VFVRN	降血脂

肽源	肽序列	生物学活性
大豆	VAWWMY（大豆抑素）	低胆固醇血症
大豆	VHVV	低胆固醇低甘油三酯血症
大豆	LUNASIN	低胆固醇血症
大豆	YPFVV（大豆蛋白⁃5）	低甘油三酯抗糖尿病
大豆	苷元	抗糖尿病
水稻	GEQQPGM	低胆固醇血症
鹰嘴豆	VFVRN	降血脂

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大豆蛋白源性肽调节糖脂代谢机制研究进展

Progress on the Mechanism of Soybean Protein Derived Peptides Regulating Glucose and Lipid Metabolism

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