关键词: 小分子药物, 抗生素, 药物靶标, 作用机理

Abstract: Many secondary metabolites produced by microbes are small molecular active compounds playing important roles in the medical and agricultural fields. A number of new research methods for small molecular drug targets have come into being driven by genomics, proteomics and bioinformatics, and these methods are based on drug-induced changes in gene or protein expression and various properties of proteins, such as compatibility and stability etc. The new methods promote the discovery of the mechanism of small molecular drugs and exploring new drug targets as resources to further screening for drugs.

Key words: small molecular drug, antibiotic, drug targets, mode of action