关键词: 帕金森病, 诱导多能干细胞, 细胞模型, 细胞移植

Abstract: Parkinson's disease (PD) is a neurodegenerative disease caused by decrease in dopamine levels from of dopaminergic neurons (DAns) in substantianigra. The existing treatment or diagnosis options are still inadequate.The presence of induced pluripotent stem cells (iPSCs) has led to the treatment of neurological disease, especially the neurodegenerative disease. The cell model based on iPSCs can carry out extensive research on the pathogenesis of PD, and the transplantation of cells such as DAns and neural stem cells (NSCs) derived from iPSCs is the most promising means for PD treatment in the future. This paper introduced the progress of induced pluripotent stem cells in PD research from two cell models based on different gene mutation types of iPSCs and cell transplantation therapy with different degrees of differentiation. The purpose of this study was to analyze the application and deficiency of induced pluripotent stem cells in Parkinson's disease.

Key words: Parkinson's disease, induced pluripotent stem cells, cell models, cell transplantation