关键词: 创伤性脑损伤, 体内模型, 体外模型, 动物模型, 细胞模型

Abstract: Traumatic brain injury (TBI) not only has higher morbidity and mortality, but also leads to varying degrees of impairment in cognitive activities and sensorimotor functions of its survivors. Establishing a reasonable TBI model helps to understand the pathophysiology of TBI and explore its treatment strategies. Many animal models of traumatic brain injury (belong to in vivo TBI models) have already been used to replicate various traumatic brain injuries in human. Unfortunately, most of the therapeutic regimens with neuroprotective effects in animal experiments proved to be ineffective in clinical studies. Since cells cultured in vitro are not adulterated with complex factors which exit in vivo, in vitro models of various traumatic brain injuries have been set up progressively. According to different types of injury, the common-used in vivo animal models and in vitro cell models are divided into physical injury model, pressure injury model, blast-induced injury model and repeated mild injury model. The characteristics of the above common-used TBI models were summarized and comparatively analyzed in order to help for the search of clinical strategies with neuroprotective effects.

Key words: traumatic brain injury, in vivo model, in vitro model, animal model, cell model