关键词: lncRNA, 脂肪发育, 脂代谢, 肥胖相关代谢疾病

Abstract: Long noncoding RNA (lncRNA) is a kind of RNA which is widely found in animals and plants, has a length of more than 200 nucleotides and cannot encode proteins. In recent years, with the continuous development of high-throughput genome sequencing technology, researchers have paid more and more attention to lncRNA. Through in-depth research on lncRNA, it has been proved that lncRNA plays an important role in many life activities such as cell differentiation, epigenetic, cell cycle regulation and so on, and the occurrence and development of many diseases are related to it. With the help of high-throughput sequencing or chip technology, it has been confirmed that many lncRNA are involved in the regulation of adipose tissue production, development and metabolism, and play an important role in the process of fat development. The study of lncRNA related to fat development can better understand the development and metabolic process of fat, and provide new methods for clinical treatment of metabolic diseases. Based on this, the researches on the  mode of action,  regulation of fat development of lncRNA and its influence on obesity-related metabolic diseases  were reviewed in order to provide theoretical guidance and direction for the research on fat development and metabolism.

Key words: lncRNA, adipogenesis, lipid metabolism, obesity-related metabolic diseases