冠状动脉疾病发病机制及治疗策略研究进展

doi:10.19586/j.2095-2341.2024.0151

生物技术进展 ›› 2025, Vol. 15 ›› Issue (2): 254-262.DOI: 10.19586/j.2095-2341.2024.0151

• 进展评述 • 上一篇

冠状动脉疾病发病机制及治疗策略研究进展

刘昊¹(), 李响²()

^1.重庆医科大学国际医学院，重庆 400016
^2.重庆医科大学附属第一医院心血管内科，重庆 400016

收稿日期:2024-09-18 接受日期:2024-12-27 出版日期:2025-03-25 发布日期:2025-04-29
通讯作者: 李响
作者简介:刘昊 E-mail: helenliuhao9@163.com；
基金资助:
重庆市教委,重庆市高等教育教学改革研究项目(232047);重庆市自然科学基金面上项目(cstc2020jcyj-msxmX1091);重庆医科大学未来医学青年创新团队支持计划(W0010)

Research Progress on Pathogenic Mechanisms and Treatment Strategy of Coronary Artery Disease

Hao LIU¹(), Xiang LI²()

^1.International Medical College of Chongqing Medical University，Chongqing 400016，China
^2.Cardiovascular Department，the First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China

Received:2024-09-18 Accepted:2024-12-27 Online:2025-03-25 Published:2025-04-29
Contact: Xiang LI

摘要/Abstract

摘要：

冠状动脉性疾病（coronary artery disease，CAD）是全球范围内导致人类死亡的首要原因之一。综述了动脉粥样硬化的病理生理特征与发病机制，重点阐述了遗传因素、炎症免疫反应以及脂质代谢异常等在动脉粥样硬化形成过程中的作用。此外，还系统分析了促进动脉粥样硬化进展的危险因素，并探讨了从预防到治疗的最新研究进展。深入揭示了动脉粥样硬化的关键致病环节，为开发新型预防和治疗策略提供了理论基础。

关键词: 冠状动脉疾病, 动脉粥样硬化, 炎症免疫, 脂质代谢, 药物治疗

Abstract:

Coronary artery disease （CAD） remains the leading cause of global mortality. This article reviewed the pathophysiology of atherosclerosis， highlighting the contributions of genetic predisposition， inflammatory immune mechanisms， and dyslipidemia to disease pathogenesis. We systematically analyzed modifiable and non-modifiable risk factors driving disease progression， while discussing recent advances in preventive strategies and therapeutic interventions. By synthesizing current knowledge of critical pathogenic pathways， this work established a conceptual framework for developing innovative approaches to combat atherosclerosis.

Key words: coronary artery disease, atherosclerosis, inflammatory immunity, lipid metabolism, pharmacotherapy

中图分类号:

Q812

刘昊, 李响. 冠状动脉疾病发病机制及治疗策略研究进展[J]. 生物技术进展, 2025, 15(2): 254-262.

Hao LIU, Xiang LI. Research Progress on Pathogenic Mechanisms and Treatment Strategy of Coronary Artery Disease[J]. Current Biotechnology, 2025, 15(2): 254-262.

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冠状动脉疾病发病机制及治疗策略研究进展

Research Progress on Pathogenic Mechanisms and Treatment Strategy of Coronary Artery Disease

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