关键词: 苯二酚内酯, 真菌聚酮, 聚酮合酶, 生物合成, 组合生物合成

Abstract: Fungal benzenediol lactones, biosynthesized by polyketide synthases, are important pharmacophores with wide-ranging bioactivities including anti-cancer and immune system modulatory effects. Its biosynthesis has become research focus in recent years. A comprehensive review was made about collaborative biosynthetic mechanism of two type I iterative polyketide synthases, and combinatorial biosynthesis of benzenediol lactones. As examples, the biosynthesis pathways of a few fungal benzenediol lactones were highlighted, which was expected provide reference for related research.

Key words: benzenediol lactone, fungal polyketides, polyketide synthase, biosynthesis, combinatorial biosynthesis