关键词: 替莫唑胺, 缓释, 局部, 颅内, 聚酸酐

Abstract: In order to overcome the toxicity and side effects of systemic administration of temozolomide, locally sustained release administration of temozolomide has become the hot research topics in recent years. This paper reviewed a number of newly locally and sustained release fomulations of temozolomide. Among them, temozolomide\|polyanhydrid (TMZ-pCPP：SA)，for its character of surface erosion, has the favourable sustained release property. The intracranial implantation test of rats indicated that TMZ-pCPP：SA had better treatment effects, less toxicity and side effects than oral administration of temozolomide. Thus, TMZ-pCPP：SA as an intracranial sustained release formulation has a bright future.

Key words: temozolomide, sunstained release, locally, intracranial, polyanhydrid