关键词: 系统生物学, 认知功能障碍, 代谢组学, 蛋白质组学, 基因组学, 肠道微生态

Abstract: Cognitive dysfunction can lead to a significant decline in daily life ability and social adaptability of patients, and seriously affect the life quality of patients. According to numerous studies in recent years, the occurrence and development of cognitive dysfunction is related to the disorders of genes, proteins, microorganisms and other internal environmental factors. In this review, based on the research of system biology, we reviewed the studies of cognitive dysfunction from the level of metabonomics, proteomics, genomics and intestinal microbiology conducted by domestic and foreign researchers in recent years, and looked forward to the application of system biology in the investigation of cognitive dysfunction, which was expected to provide reference for related research of cognitive dysfunction.

Key words: systems biology, cognitive dysfunction, metabonomics, proteomics, genomics, intestinal microecology