生物技术进展 ›› 2017, Vol. 7 ›› Issue (4): 320-326.DOI: 10.19586/j.2095-2341.2016.0126

• 研究论文 • 上一篇    下一篇

玉米微孔淀粉制备止血剂研究

边文海1§,刘成程2§,李倩2,王超展1*,边六交2   

  1. 1.西北大学化学与材料科学学院, 西安 710069;2.西北大学生命科学学院, 西安 710069
  • 收稿日期:2016-10-29 出版日期:2017-07-25 发布日期:2017-01-20
  • 通讯作者: 王超展，教授，主要从事新型分离材料制备与应用及色谱分析研究。E-mail：czwang@nwu.edu.cn
  • 作者简介:§边文海与刘成程为本文共同第一作者。边文海，本科生，主要从事微孔淀粉制备及应用研究。E-mail：837758820@qq.com。刘成程，硕士研究生，主要从事微孔淀粉制备及应用研究。
  • 基金资助:
    陕西省科技统筹创新工程计划项目（2016KTCQ02-18）；陕西省科技研究发展（攻关）计划项目（2013K01-48-01）资助。

Research on the Hemostatic Preparation with Corn Microporous Starch

BIAN Wenhai, LIU Chengcheng, LI Qian, WANG Chaozhan, BIAN Liujiao   

  1. 1.College of Chemistry and Materials Science, Northwest University, Xi′an 710069, China;
    2.College of Life Sciences, Northwest University, Xi′an 710069, China
  • Received:2016-10-29 Online:2017-07-25 Published:2017-01-20

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摘要： 为了制备玉米微孔淀粉止血剂，并对止血剂性能进行评价研究，采用酸酶序解法制备玉米微孔淀粉，测定其孔密度和吸水率，用动物创面出血模型检验其止血效果。研究结果显示，该方法所得微孔淀粉孔密度为3.4×104 /mm2，吸水率为156.98%，无病原微生物和内毒素；兔耳创面和兔肝脏创面完全止血时间分别在140 s和80 s之内，止血迅速、牢固，优于云南白药。研究结果表明，该微孔淀粉组织相容性良好，符合生物材料安全性的要求，可望开发为新型止血材料。

关键词: 玉米淀粉, 微孔淀粉, 止血剂, 生物相容性

Abstract: To prepare and evaluate the hemostatic that made of corn microporous starch, a sequential hydrochloric acid and composite enzyme hydrolysis method was utilized for preparation of corn microporous starch. The density and water-absorbing ratio of the microporous starch were determined. The hemostatic effect was evaluated by animal wound hemorrhage model. Results showed that, the density and water-absorbing ratio of the microporous starch were determined to be 3.4×104 /mm2 and 156.98%, respectively. The microorganism and endotoxin had  been picked out. The hemostatic time of the microporous starch to the rabbit ear and liver trauma were within 140 s and 80 s, and the hemostasis effect was superior to Yunnan Baiyao. The microporous starch had good biocompatibility and met the safety criterion of biomaterial. It has potential to be a promising biomaterial for hemostasis.

Key words: corn starch, microporous starch, hemostatic, biocompatibility

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