关键词: 灵芝酸枣仁胶囊, 小鼠, 改善睡眠

Abstract: The function of Ganoderma lucidum Semen Ziziphi Spinosae Capsules (GLSZSC) on sleep improvement  was studied. ICR mice were randomly divided into normal control and GLSZSC (225 mg/kg, 450 mg/kg and 1 350 mg/kg) groups and each group with 12 mice. After giving GLSZSC via gavage for 30 days, the effect on sleep improvement was studied by the experiments of sleep-induced directly, prolonging sleep time induced by pentobarbital sodium and affecting mice barbital sodium, respectively. Compared with normal control group, the GLSZSC did not have directly sleep-induced function, whereas the GLSZSC (450 mg/kg and 1 350 mg/kg) could significantly prolong the sleep time induced by pentobarbital sodium (P<0.01 and P<005). The GLSZSC (1 350 mg/ kg) decreased the number of mice in sleep latency induced by barbital sodium (P<0.01) and increased the number of mice in sleep under the threshold hypnogenesis dosage of barbital sodium (P<0.05) obviously. The research showed that GLSZSC had certain effect on improving sleep of mice.

Key words: Ganoderma lucidum Semen Ziziphi Spinosae Capsules, mice, sleep improvement