关键词: 乳腺癌, T型钙通道, 肿瘤治疗

Abstract: T-type calcium channel is a voltage-dependent calcium channel, with a low activation potential, fast inactivation and small single-channel conductance. It has high tissue specificity, highlighting physiological functions and pharmacology. Recent studies show that T-type calcium channel is involved in intracellular calcium flow oscillation and the process of tumor cell proliferation by unique activation and inactivation. It is note worthy that there is no expression of these channels in normal human mammary epithelial cells, but the distribution in different differentiation stages of breast cancer cells is amazing. The experiments confirmed that expression of T-type calcium channel is positively correlated with the proliferation of breast cells, and the channel blocker can reduce the breast cancer cells proliferation significantly. This discovery provides a new way to think about diagnosis and treatment of breast cancer and drug development. This article outlines the recent research about T-type calcium channel and the breast cancer.

Key words: breast cancer, T-type calcium channels, cancer treatment